Evidence map›Paper›PMID 39322280›Full record

ArticleGenome research2024

Mutational scanning of

James L Shepherdson, David M Granas, Jie Li, Zara Shariff, Stephen P Plassmeyer, Alex S Holehouse, Michael A White, Barak A Cohen

Abstract read
In one paragraph

Article in Genome research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Article
  11. MaveMD: A functional data resource for genomic medicine.medRxiv : the preprint server for health sciences · 2025
    Article
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

James L ShepherdsonDepartment of Genetics, Washington University School of Medicine in St. Louis, St. Louis, Missouri 63110, USA.ORCID 0000-0002-3288-7000
David M GranasDepartment of Genetics, Washington University School of Medicine in St. Louis, St. Louis, Missouri 63110, USA.
Jie LiDepartment of Genetics, Washington University School of Medicine in St. Louis, St. Louis, Missouri 63110, USA.
Zara ShariffDepartment of Genetics, Washington University School of Medicine in St. Louis, St. Louis, Missouri 63110, USA.ORCID 0009-0006-3134-2945
Stephen P PlassmeyerDepartment of Biochemistry and Molecular Biophysics, Washington University School of Medicine in St. Louis, St. Louis, Missouri 63110, USA.ORCID 0000-0002-8986-0650
Alex S HolehouseDepartment of Biochemistry and Molecular Biophysics, Washington University School of Medicine in St. Louis, St. Louis, Missouri 63110, USA.ORCID 0000-0002-4155-5729
Michael A WhiteDepartment of Genetics, Washington University School of Medicine in St. Louis, St. Louis, Missouri 63110, USA.ORCID 0000-0001-8511-6026
Barak A CohenDepartment of Genetics, Washington University School of Medicine in St. Louis, St. Louis, Missouri 63110, USA; cohen@wustl.edu.ORCID 0000-0002-3350-2715

Funding

Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI TIMOTHY J. EBERLEIN · 2001 to 2026
$128.0M
PROMOTERSR01GM092910 · NIGMS · WASHINGTON UNIVERSITY · PI Barak A Cohen · 2011 to 2026
$6.6M
Uncovering the regulatory logic of gene expression encoded by disordered regionsDP2CA290639 · NCI · WASHINGTON UNIVERSITY · PI Alex S Holehouse · 2023 to 2026
$2.3M
DISCOVERY OF DNA DETERMINANTS OF TRANSCRIPTION FACTOR BINDING AND FUNCTION IN PHOR01GM121755 · NIGMS · WASHINGTON UNIVERSITY · PI WHITE, MICHAEL AARON · 2017 to 2021
$1.5M
CIS-REGULATORY MECHANISMS UNDERLYING RETINOPATHYR01EY027784 · NEI · WASHINGTON UNIVERSITY · PI CHEN, SHIMING, COHEN, BARAK A · 2017 to 2020
$1.4M
Cell-Based Assays For Deep Mutational Scans of Transcription FactorsR21HG012146 · NHGRI · WASHINGTON UNIVERSITY · PI COHEN, BARAK A · 2021 to 2021
$433k
Multiplex functional assay of variant effect in the retinal transcription factor CRXF30EY033640 · NEI · WASHINGTON UNIVERSITY · PI SHEPHERDSON, JAMES LEWIS · 2022 to 2025
$178k
NCI NIH HHS DP2 CA290639NCI NIH HHS P30 CA091842NEI NIH HHS F30 EY033640NEI NIH HHS R01 EY027784NHGRI NIH HHS R21 HG012146NIGMS NIH HHS R01 GM092910NIGMS NIH HHS R01 GM121755
6 · The paper itself

Abstract

The transcription factor (TF) cone-rod homeobox (CRX) is essential for the differentiation and maintenance of photoreceptor cell identity. Several human

Indexed as

Homeodomain ProteinsTrans-ActivatorsAmino Acid SubstitutionDNA Mutational AnalysisGenetic VariationHumansMutationProtein Domainscone rod homeobox proteinHomeodomain ProteinsTrans-Activators

Identifiers

PMID39322280
PMCPMC11529990

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.