Evidence map›Paper›PMID 39322039›Full record

SynthesisIndian heart journal

Safety and efficacy of protamine after transcatheter aortic valve replacement.

Lakshmi Durga Kumaraguruparan, Asuwin Anandaram, Kamalakkannan G Sambandam, Yogapriya Chidambaram, Bharath Raj Kidambi, Gautam Ganesan Karthikeyan, Madhesh Kasi, Rizwan Suliankatchi Abdulkader, Sankaran Ramesh, Vadivelu Ramalingam and 2 more

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Indian heart journal. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Lakshmi Durga KumaraguruparanDepartment of Cardiology, Sri Ramachandra Institute of Higher Education and Research (SRIHER), No.1, Ramachandra Nagar, Porur, Chennai, Tamil Nadu, 600116, India. Electronic address: laks.kld@gmail.com.
Asuwin AnandaramDepartment of Internal Medicine, Lehigh Valley Health Network, Allentown, PA, 18101, United States. Electronic address: asuwin99@gmail.com.
Kamalakkannan G SambandamDepartment of Cardiac Anaesthesia, Sri Ramachandra Institute of Higher Education and Research (SRIHER), No.1, Ramachandra Nagar, Porur, Chennai, Tamil Nadu, 600116, India. Electronic address: anaeskamal2006@gmail.com.
Yogapriya ChidambaramDepartment of Clinical Research, Sri Ramachandra Institute of Higher Education and Research (SRIHER), No.1, Ramachandra Nagar, Porur, Chennai, Tamil Nadu, 600116, India. Electronic address: yogapriyac96@gmail.com.
Bharath Raj KidambiDepartment of Cardiology, AI Dhannah Hospital, Ruwais, Abu Dhabi, United Arab Emirates. Electronic address: drbkid@gmail.com.
Gautam Ganesan KarthikeyanDepartment of Cardiology, PSRI Hospital, New Delhi, India. Electronic address: gautam1998@gmail.com.
Madhesh KasiDepartment of Clinical Research, Sri Ramachandra Institute of Higher Education and Research (SRIHER), No.1, Ramachandra Nagar, Porur, Chennai, Tamil Nadu, 600116, India. Electronic address: kmadhesh19498@gmail.com.
Rizwan Suliankatchi AbdulkaderNational Institute of Epidemiology, ICMR, Chennai & Department of Statistics, Manonmaniam Sundaranar University, Abishekapatti, Tirunelveli, Tamil Nadu, India. Electronic address: sarizwan1986@gmail.com.
Sankaran RameshDepartment of Cardiology, Sri Ramachandra Institute of Higher Education and Research (SRIHER), No.1, Ramachandra Nagar, Porur, Chennai, Tamil Nadu, 600116, India. Electronic address: sankaranramesh39@gmail.com.
Vadivelu RamalingamDepartment of Cardiology, Velammal Medical College and Hospital, Madurai, India. Electronic address: vvelu00@gmail.com.
Ravindran RajendranDepartment of Cardiology, Apollo Hospitals, Trichy, India. Electronic address: rravindranrajendran@gmail.com.
Nagendra Boopathy SenguttuvanDepartment of Cardiology, Sri Ramachandra Institute of Higher Education and Research (SRIHER), No.1, Ramachandra Nagar, Porur, Chennai, Tamil Nadu, 600116, India. Electronic address: nagendraboopathy@sriramachandra.edu.in.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Transfemoral Trans-catheter Aortic Valve Replacement (TF-TAVR) is a safe alternative to surgical aortic valve replacement (SAVR). Protamine is used to reverse heparin and reduce post-TAVR bleeding, but concerns about risks like valve thrombosis and stroke remain. This systematic review and meta-analysis, following PRISMA guidelines, found no statistically significant difference in major bleeding complications between the protamine and control groups [(3.0 % vs. 14.4 %); RR: 0.56; P = 0.16]. No differences were noted in life-threatening bleeding, blood transfusions, 30-day mortality, or stroke. Protamine appears safe post-TAVR without increasing stroke risk, but its effectiveness in reducing bleeding needs further investigation through a multicentric randomized study.

Indexed as

Aortic Valve StenosisHeparin AntagonistsProtaminesTranscatheter Aortic Valve ReplacementAortic ValveHumansPostoperative HemorrhageTreatment OutcomeHeparin AntagonistsProtaminesProtamineTransfemoral Trans-catheter aortic valve replacementVascular complications

Identifiers

PMID39322039
PMCPMC11584372

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.