Evidence map›Paper›PMID 39321909›Full record

ArticleThe journal of pain2024

TRPA1 Agonist-Responsive Afferents Contribute to Central Sensitization by Suppressing Spinal GABAergic Interneurons Through Somatostatin 2A Receptors.

Ramesh Pariyar, Jigong Wang, Regan Hammond, Ho Koo, Nicholas Dalley, Jun-Ho La

Erratum issuedAbstract read
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In one paragraph

Article in The journal of pain, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Ramesh PariyarDepartment of Neurobiology, The University of Texas Medical Branch, Galveston, Texas.
Jigong WangDepartment of Neurobiology, The University of Texas Medical Branch, Galveston, Texas.
Regan HammondDepartment of Neurobiology, The University of Texas Medical Branch, Galveston, Texas.
Ho KooDepartment of Neurobiology, The University of Texas Medical Branch, Galveston, Texas.
Nicholas DalleyDepartment of Neurobiology, The University of Texas Medical Branch, Galveston, Texas.
Jun-Ho LaDepartment of Neurobiology, The University of Texas Medical Branch, Galveston, Texas. Electronic address: jula@utmb.edu.

Funding

Mechanisms of chronic pain maintained by ongoing nociceptor inputs in femalesR01NS112344 · NINDS · UNIVERSITY OF TEXAS MED BR GALVESTON · PI LA, JUN-HO · 2019 to 2023
$1.7M
NINDS NIH HHS R01 NS112344
6 · The paper itself

Abstract

Altered nociception, a key feature of nociplastic pain, often involves central sensitization. We previously found that central sensitization underlying a nociplastic pain state in female mice depends on the ongoing activity of TRPA1 agonist-responsive afferents. Here, we investigated how the activity of these afferents induces and maintains central sensitization at the spinal level. We hypothesized that, in the superficial dorsal horn where somatostatin (SST) is expressed in excitatory interneurons and the SST2A receptor (SST2A-R) in GABAergic inhibitory interneurons (GABAn), TRPA1 agonist-responsive afferents stimulate SST-expressing excitatory interneurons (SSTn), leading to GABAn suppression through SST2A-R and resulting in altered nociception. We tested this hypothesis using ex vivo Ca

Indexed as

InterneuronsReceptors, SomatostatinTRPA1 Cation ChannelAnimalsCentral Nervous System SensitizationFemaleGABAergic NeuronsHyperalgesiaIsothiocyanatesMiceMice, Inbred C57BLMice, TransgenicNociceptionSpinal CordIsothiocyanatesReceptors, Somatostatinsomatostatin receptor sst2ATRPA1 Cation ChannelTrpa1 protein, mouseSomatostatin, GABAergic neuron, SST2A receptor, nociplastic pain, central sensitization

Identifiers

PMID39321909
PMCPMC11560608

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.