Evidence map›Paper›PMID 39321846›Full record

ArticleNature2025

H5N1 clade 2.3.4.4b dynamics in experimentally infected calves and cows.

Nico Joel Halwe, Konner Cool, Angele Breithaupt, Jacob Schön, Jessie D Trujillo, Mohammed Nooruzzaman, Taeyong Kwon, Ann Kathrin Ahrens, Tobias Britzke, Chester D McDowell and 18 more

Abstract read
In one paragraph

Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 116 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
116citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

116 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Quantitative Microbial Risk Assessment of Human H5N1 Infection From Consumption of Fluid Cow's Milk.Risk analysis : an official publication of the Society for Risk Analysis · 2026
    Article
  17. Article
  18. Article
  19. Detection of antibodies against avian influenza in European dairy cattle, the Netherlands, January 2026.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2026
    Article
  20. Article

56 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors.

Nico Joel Halwe *Institute of Diagnostic Virology, Friedrich-Loeffler-Institut, Greifswald - Insel Riems, Germany.ORCID 0000-0002-7983-2808
Konner Cool *Department of Diagnostic Medicine/Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS, USA.ORCID 0000-0003-3666-0214
Angele Breithaupt *Department of Experimental Animal Facilities and Biorisk Management, Friedrich-Loeffler-Institut, Greifswald - Insel Riems, Germany.ORCID 0000-0002-6373-5923
Jacob Schön *Institute of Diagnostic Virology, Friedrich-Loeffler-Institut, Greifswald - Insel Riems, Germany.ORCID 0000-0002-9801-7972
Jessie D Trujillo *Department of Diagnostic Medicine/Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS, USA.
Mohammed NooruzzamanDepartment of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA.ORCID 0000-0002-9358-1494
Taeyong KwonDepartment of Diagnostic Medicine/Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS, USA.
Ann Kathrin AhrensInstitute of Diagnostic Virology, Friedrich-Loeffler-Institut, Greifswald - Insel Riems, Germany.ORCID 0009-0007-3635-423X
Tobias BritzkeDepartment of Experimental Animal Facilities and Biorisk Management, Friedrich-Loeffler-Institut, Greifswald - Insel Riems, Germany.ORCID 0009-0001-8177-4766
Chester D McDowellDepartment of Diagnostic Medicine/Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS, USA.ORCID 0000-0001-8452-7288
Ronja PiescheInstitute of Diagnostic Virology, Friedrich-Loeffler-Institut, Greifswald - Insel Riems, Germany.
Gagandeep SinghDepartment of Diagnostic Medicine/Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS, USA.ORCID 0000-0003-3260-2631
Vinicius Pinho Dos ReisInstitute of Diagnostic Virology, Friedrich-Loeffler-Institut, Greifswald - Insel Riems, Germany.
Sujan KafleDepartment of Diagnostic Medicine/Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS, USA.ORCID 0009-0001-0423-6745
Anne PohlmannInstitute of Diagnostic Virology, Friedrich-Loeffler-Institut, Greifswald - Insel Riems, Germany.ORCID 0000-0002-5318-665X
Natasha N GaudreaultDepartment of Diagnostic Medicine/Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS, USA.
Björn CorleisInstitute of Immunology, Friedrich-Loeffler-Institut, Greifswald - Insel Riems, Germany.
Franco Matias FerreyraVeterinary Diagnostic Laboratory, College of Veterinary Medicine, Kansas State University, Manhattan, KS, USA.
Mariano CarossinoLouisiana Animal Disease Diagnostic Laboratory, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA, USA.ORCID 0000-0003-3864-5915
Udeni B R BalasuriyaLouisiana Animal Disease Diagnostic Laboratory, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA, USA.
Lisa HensleyZoonotic and Emerging Disease Research Unit, National Bio and Agro-Defense Facility, Agricultural Research Service, United States Department of Agriculture, Manhattan, KS, USA.
Igor MorozovDepartment of Diagnostic Medicine/Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS, USA.
Lina M CovaledaDepartment of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA.
Diego G DielDepartment of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA.ORCID 0000-0003-3237-8940
Lorenz UlrichInstitute of Diagnostic Virology, Friedrich-Loeffler-Institut, Greifswald - Insel Riems, Germany.ORCID 0000-0001-5004-806X
Donata HoffmannInstitute of Diagnostic Virology, Friedrich-Loeffler-Institut, Greifswald - Insel Riems, Germany.ORCID 0000-0003-4552-031X
Martin BeerInstitute of Diagnostic Virology, Friedrich-Loeffler-Institut, Greifswald - Insel Riems, Germany. martin.beer@fli.de.ORCID 0000-0002-0598-5254
Juergen A RichtDepartment of Diagnostic Medicine/Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS, USA. jricht@vet.k-state.edu.ORCID 0000-0001-7308-5672

Funding

NIAID Centers of Excellence for Influenza Research and Response: Universal Influenza Vaccine Research Activities75N93021C00016 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI WEBBY, RICHARD · 2021 to 2025
$91.4M
Sex-specific effects of obestity on Influenza A virus infection and immunityP20GM130448 · NIGMS · KANSAS STATE UNIVERSITY · PI REVATHI GOVIND · 2020 to 2026
$15.8M
NIAID NIH HHS 75N93021C00016NIGMS NIH HHS P20 GM130448
6 · The paper itself

Abstract

In March 2024, highly pathogenic avian influenza virus (HPAIV) clade 2.3.4.4b H5N1 infections were reported in dairy cows in Texas, USA

Indexed as

Cattle DiseasesInfluenza A Virus, H5N1 SubtypeOrthomyxoviridae InfectionsAnimalsCattleDisease SusceptibilityFemaleGenotypeLactationMammary Glands, AnimalMilkNoseTexasVirus ReplicationVirus Shedding

Identifiers

PMID39321846
PMCPMC11754106

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.