ArticleImmunity2024
Multidimensional profiling of human T cells reveals high CD38 expression, marking recent thymic emigrants and age-related naive T cell remodeling.
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Article in Immunity, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 2 of them syntheses that pooled it.
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45citing papers in PubMed, 2 pooled it
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Who cites it
45 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Unveiling the role of NAD glycohydrolase CD38 in aging and age-related diseases: insights from bibliometric analysis and comprehensive review.Frontiers in immunology · 2025Pooled it
- Systematic review and quantitative meta-analysis of age-dependent human T-lymphocyte homeostasis.Frontiers in immunology · 2025Pooled it
- Lymph node contraction links sex-biased naive CD8Nature aging · 2026Article
- Thymic function as a central determinant of immune competence and clinical outcomes.Seminars in immunopathology · 2026Review
- Single-cell mapping of thymus-dependent naïve t-cell regeneration reveals CD61-associated states after hematopoietic stem cell transplantation.Experimental hematology & oncology · 2026Article
- Sex-specific trajectories of nonlinear immune aging at single-cell level.Nature communications · 2026Article
- A single-cell atlas of porcine hematopoietic development.Nature communications · 2026Article
- Immuno-Proteomic Features Associated to Relapse Risk in Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease.Neurology(R) neuroimmunology & neuroinflammation · 2026Article
- Differential cytokine architecture in patients treated with CART19 versus CART22.Journal for immunotherapy of cancer · 2026Article
- Immune responses in aging adults.The Journal of clinical investigation · 2026Review
- Single-cell map of the healthy human immune system across the lifespan reveals unique infant immune signatures.Nature communications · 2026Article
- Variants in human CD48 lead to impaired T cell immunity and increased inflammation.The Journal of clinical investigation · 2026Article
- Epigenetic programming by H3K23ac defines lineage fate of Meg3Nature cell biology · 2026Article
- PD-1 regulates latent effector differentiation of thymic cytotoxic CD8Nature communications · 2026Article
- Sustained Effector Functions and Memory Accumulation of αβ T Cells in Children With Congenital Heart Disease.European journal of immunology · 2026Article
- CD38 expression by neonatal human naive CD4+ T cells shapes their distinct metabolic and tolerogenic properties.The Journal of clinical investigation · 2026Article
- Altered Cytokine-Induced STAT3 and STAT5 Activation of Peripheral T Follicular Helper Cells Contributes to Vaccine-Non-Responsiveness in Aging and HIV.Aging cell · 2026Article
- Flow Cytometry Role in Unlocking New Frontiers for Nanomedicine Applications of Plant-Derived Vesicles.Journal of extracellular biology · 2026Review
- Interleukin-6 restricts pre-thymic T cell lineage commitment of progenitors driving loss of SIV control.bioRxiv : the preprint server for biology · 2026Article
- Expression of CD38 on resting peripheral iNKT cells defines an immature subpopulation with distinct functionality in humans.Immunology and cell biology · 2026Article
Corrections and comments
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Authors and funding
24 authors.
Pavla BohacovaDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Marina TerekhovaDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Petr TsurinovJetBrains Research, Paphos 8021, Cyprus.
Riley MullinsDepartment of Otolaryngology-Head and Neck Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA.
Kamila HusarcikovaDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Irina ShchukinaDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Alina Ulezko AntonovaDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Barbora EchalarDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Jan KosslDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Adam SaiduDepartment of Emergency Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Thomas FrancisCentre for Human and Applied Physiological Sciences, School of Basic and Medical Biosciences, Faculty of Life Sciences & Medicine, King's College London, London SE1 1UL, UK.
Chelsea MannieDivision of Cardiothoracic Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA.
Laura ArthurDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Stephen D R HarridgeCentre for Human and Applied Physiological Sciences, School of Basic and Medical Biosciences, Faculty of Life Sciences & Medicine, King's College London, London SE1 1UL, UK.
Daniel KreiselDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA.
Philip A MuddDepartment of Emergency Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA; The Andrew M. and Jane M. Bursky Center for Human Immunology & Immunotherapy Programs, Washington University School of Medicine, St. Louis, MO 63110, USA; Center for Vaccines and Immunity to Microbial Pathogens, Washington University School of Medicine, St. Louis, MO 63110, USA.
Angela M TaylorDepartment of Medicine, Cardiovascular Division, University of Virginia, Charlottesville, VA 22903, USA.
Coleen A McNamaraDepartment of Medicine, Cardiovascular Division, University of Virginia, Charlottesville, VA 22903, USA; Beirne B. Carter Center for Immunology Research, University of Virginia, Charlottesville, VA 22903, USA.
Marina CellaDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Sidharth V PuramDepartment of Otolaryngology-Head and Neck Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA; Rob Ebert and Greg Stubblefield Head and Neck Tumor Center at Siteman Cancer Center, St. Louis, MO 63110, USA.
Theo van den BroekCenter for Translational Immunology, University Medical Centre Utrecht, Utrecht University, Utrecht 3584CX, the Netherlands.
Femke van WijkCenter for Translational Immunology, University Medical Centre Utrecht, Utrecht University, Utrecht 3584CX, the Netherlands.
Pirooz EghtesadyDivision of Cardiothoracic Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA.
Maxim N ArtyomovDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address: martyomov@wustl.edu.
Funding
Project 4: APOB-specific CD4 and CD8 T cells exacerbate atherosclerosisP01HL136275 · NHLBI · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI Catherine C Hedrick · 2017 to 2026
$25.5MNHLBI NIH HHS P01 HL136275
Abstract
Thymic involution is a key factor in human immune aging, leading to reduced thymic output and a decline in recent thymic emigrant (RTE) naive T cells in circulation. Currently, the precise definition of human RTEs and their corresponding cell surface markers lacks clarity. Analysis of single-cell RNA-seq/ATAC-seq data distinguished RTEs by the expression of SOX4, IKZF2, and TOX and CD38 protein, whereby surface CD38
Indexed as
ADP-ribosyl Cyclase 1AgingCD8-Positive T-LymphocytesThymus GlandAdultAgedAged, 80 and overCD4-Positive T-LymphocytesFemaleGene Expression ProfilingHumansMaleMembrane GlycoproteinsMiddle AgedReceptors, CXCR3Single-Cell AnalysisADP-ribosyl Cyclase 1CD38 protein, humanCXCR3 protein, humanMembrane GlycoproteinsReceptors, CXCR3aginghumannaive T cellsPBMCrecent thymic emigrants
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.