ArticleNeuron2024
Ventral frontostriatal circuitry mediates the computation of reinforcement from symbolic gains and losses.
Article in Neuron, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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11 citing papers in PubMed.
- Complementary and opponent value signals in the human brain support choosing the best and avoiding the worst.Nature communications · 2026Article
- Neuronal dynamics, timing, and flow of sensory and choice-related information in auditory-prefrontal circuitry.Nature communications · 2026Article
- Long-term Learning Induces Plastic Changes in Frontostriatal Circuits.bioRxiv : the preprint server for biology · 2026Article
- Synaptic pruning, myelination and the emergence of psychiatric disorders in late adolescence.bioRxiv : the preprint server for biology · 2026Article
- Prefrontal modulation of striatal engagement: a hierarchical framework for goal-directed behavior.Communications biology · 2026Review
- Neural representation of the decisional reference point in monkeys.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Chemogenetic Disruption of Monkey Perirhinal Neurons Projecting to the Rostromedial Caudate Impairs Associative Learning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Non-human primates can flexibly learn serial sequences and reorder context-dependent object sequences.PLoS biology · 2025Article
- Home-Cage Training for Non-Human Primates: An Opportunity to Reduce Stress and Study Natural Behavior in Neurophysiology Experiments.Animals : an open access journal from MDPI · 2025Review
- Elaborating the connections of a closed-loop forebrain circuit in the rat: Circumscribed evidence for novel topography within a cortico-striato-pallidal triple descending projection, with thalamic feedback, to the anterior lateral hypothalamic area.bioRxiv : the preprint server for biology · 2025Article
- The amygdala and the pursuit of future rewards.Frontiers in neuroscience · 2024Review
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Abstract
Reinforcement learning (RL), particularly in primates, is often driven by symbolic outcomes. However, it is usually studied with primary reinforcers. To examine the neural mechanisms underlying learning from symbolic outcomes, we trained monkeys on a task in which they learned to choose options that led to gains of tokens and avoid choosing options that led to losses of tokens. We then recorded simultaneously from the orbitofrontal cortex (OFC), ventral striatum (VS), amygdala (AMY), and mediodorsal thalamus (MDt). We found that the OFC played a dominant role in coding token outcomes and token prediction errors. The other areas contributed complementary functions, with the VS coding appetitive outcomes and the AMY coding the salience of outcomes. The MDt coded actions and relayed information about tokens between the OFC and VS. Thus, the OFC leads the processing of symbolic RL in the ventral frontostriatal circuitry.
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