ArticleNeuron2024
Ventral hippocampal parvalbumin interneurons gate the acute anxiolytic action of the serotonergic psychedelic DOI.
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Article in Neuron, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16citing papers in PubMed
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Who cites it
16 citing papers in PubMed.
- The ventral hippocampus: computations, circuits and functions.Nature reviews. Neuroscience · 2026Review
- Ibogaine induces juvenile-like plasticity and modulates functional and structural regulators of plasticity in the adult mouse visual cortex.BMC neuroscience · 2026Article
- Article
- Psilocybin reshapes cortical inhibition through selective interneuron recruitment.bioRxiv : the preprint server for biology · 2026Article
- Pretreatment with the psychedelic DOI mitigates LPS-induced hippocampal inflammation and behavioral impairments in mice.BMC neuroscience · 2026Article
- vCA1 SST neurons represent avoidance states that guide anxiety-related behavioral choices.bioRxiv : the preprint server for biology · 2026Article
- Psychedelic Modulation of Excitation/Inhibition Balance: A Dual-Phase Neurodevelopmental Model.ACS chemical neuroscience · 2026Review
- Sex Differences in the Ventral Subiculum's Microcircuitry and Function.Hippocampus · 2026Review
- Rethinking parvalbumin: From passive marker to active modulator of hippocampal circuits.IBRO neuroscience reports · 2025Article
- The ABCs of psychedelics: a preclinical roadmap for drug discovery.Trends in pharmacological sciences · 2025Review
- Sex-specific role of the 5-HTNature communications · 2025Article
- Modelling fragile X-associated neuropsychiatric disorders in young inducible 90CGG premutation mice.Brain : a journal of neurology · 2025Article
- Psychedelics for anxiety disorders: Challenges and opportunities.Fundamental research · 2025Article
- A multi-institutional investigation of psilocybin's effects on mouse behavior.bioRxiv : the preprint server for biology · 2025Article
- Article
- Parvalbumin interneurons: the dark and bright sides of a key playmaker of neural circuits and behavior.Frontiers in cellular neuroscience · 2025Review
Corrections and comments
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Authors and funding
16 authors.
Praachi TiwariDepartment of Biological Sciences, Tata Institute of Fundamental Research, Mumbai 400005, India. Electronic address: praachi.tiwari@tifr.res.in.
Pasha A DavoudianMedical Scientist Training Program, Yale University School of Medicine, New Haven, CT 06511, USA; Interdepartmental Neuroscience Program, Yale University School of Medicine, New Haven, CT 06511, USA.
Darshana KapriDepartment of Biological Sciences, Tata Institute of Fundamental Research, Mumbai 400005, India.
Ratna Mahathi VuruputuriDepartment of Biological Sciences, Tata Institute of Fundamental Research, Mumbai 400005, India.
Lindsay A KarabaDepartment of Neurobiology and Behavior, Cornell University, Ithaca, NY, USA.
Mukund SharmaDepartment of Biological Sciences, Tata Institute of Fundamental Research, Mumbai 400005, India.
Giulia ZanniDepartment of Psychiatry, Columbia University, New York, NY 10032, USA; Department of Developmental Neuroscience, New York State Psychiatric Institute, New York, NY 10032, USA.
Angarika BalakrishnanDepartment of Biological Sciences, Tata Institute of Fundamental Research, Mumbai 400005, India.
Pratik R ChaudhariDepartment of Biological Sciences, Tata Institute of Fundamental Research, Mumbai 400005, India.
Amartya PradhanDepartment of Biological Sciences, Tata Institute of Fundamental Research, Mumbai 400005, India.
Shital SuryavanshiDepartment of Biological Sciences, Tata Institute of Fundamental Research, Mumbai 400005, India.
Kevin G BathDepartment of Psychiatry, Columbia University, New York, NY 10032, USA; Department of Developmental Neuroscience, New York State Psychiatric Institute, New York, NY 10032, USA.
Mark S AnsorgeDepartment of Psychiatry, Columbia University, New York, NY 10032, USA; Department of Developmental Neuroscience, New York State Psychiatric Institute, New York, NY 10032, USA.
Antonio Fernandez-RuizDepartment of Neurobiology and Behavior, Cornell University, Ithaca, NY, USA.
Alex C KwanDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT 06511, USA; Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY 14853, USA; Department of Psychiatry, Weill Cornell Medicine, New York, NY 10065, USA.
Vidita A VaidyaDepartment of Biological Sciences, Tata Institute of Fundamental Research, Mumbai 400005, India. Electronic address: vvaidya@tifr.res.in.
Funding
MEDICAL SCIENTIST TRAINING PROGRAMT32GM007205 · NIGMS · YALE UNIVERSITY · PI KAZMIERCZAK, BARBARA I · 1985 to 2019
$42.9MDevelopmental Origins of Aggressive and Impulsive BehaviorR01MH132911 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI Mark Sascha Ansorge · 2023 to 2026
$3.1MCellular basis of psilocybin actions in frontal cortexR01MH128217 · NIMH · CORNELL UNIVERSITY · PI CHUN-HAY ALEX KWAN · 2022 to 2026
$2.9MMechanisms driving sex differences in cognitive outcomes following early life stressR01MH115049 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI BATH, KEVIN GEORGE · 2018 to 2022
$2.7MA Dendritic Substrate for Fast-Acting Antidepressant ActionR01MH121848 · NIMH · YALE UNIVERSITY · PI KWAN, CHUN-HAY ALEX · 2020 to 2024
$2.6MHow do animals learn the structure of their natural environment?DP2MH136496 · NIMH · CORNELL UNIVERSITY · PI Antonio Fernandez-Ruiz · 2023 to 2026
$2.5MEarly Life Stress Effects on Threat LearningR01MH115914 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI BATH, KEVIN GEORGE · 2018 to 2022
$2.2MRole of cortical GABAergic interneurons in psychedelic drug actionR01MH137047 · NIMH · CORNELL UNIVERSITY · PI CHUN-HAY ALEX KWAN · 2024 to 2026
$1.9MHippocampo-cortical circuit mechanisms of neuronal sequences during learningR00MH120343 · NIMH · CORNELL UNIVERSITY · PI FERNANDEZ-RUIZ, ANTONIO · 2021 to 2023
$747kRole of serotonin brain circuit in the developmental emergence ofinnate fearK01MH131895 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI Giulia Zanni · 2023 to 2026
$721kSubcortical targets involved in the action of psilocybin in learned and innate escape behaviorsF30DA059437 · NIDA · YALE UNIVERSITY · PI DAVOUDIAN, PASHA A · 2023 to 2025
$141kNIDA NIH HHS F30 DA059437NIGMS NIH HHS T32 GM007205NIMH NIH HHS DP2 MH136496NIMH NIH HHS K01 MH131895NIMH NIH HHS R00 MH120343NIMH NIH HHS R01 MH115049NIMH NIH HHS R01 MH115914NIMH NIH HHS R01 MH121848NIMH NIH HHS R01 MH128217NIMH NIH HHS R01 MH132911NIMH NIH HHS R01 MH137047
Abstract
There has been a recent renewal of interest in the therapeutic potential of serotonergic psychedelics. Here, we uncover the essential role of ventral hippocampus (vHpc) GABAergic interneurons in the anxiolytic effect evoked by the serotonergic psychedelic 2,5-dimethoxy-4-iodoamphetamine (DOI). Integrating anatomical, pharmacological, and genetic approaches, we show that 5-HT
Indexed as
AmphetaminesAnti-Anxiety AgentsHallucinogensHippocampusInterneuronsParvalbuminsReceptor, Serotonin, 5-HT2AAnimalsCA1 Region, HippocampalMaleMiceMice, Inbred C57BL4-iodo-2,5-dimethoxyphenylisopropylamineAmphetaminesAnti-Anxiety AgentsHallucinogensParvalbuminsReceptor, Serotonin, 5-HT2A2,5-dimethoxy-4-iodoamphetamine5-HT(2A) receptoranxietyCA1fast-spiking cellssubiculum
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.