ArticleThe Plant cell2024
The transcription factor CAMTA2 interacts with the histone acetyltransferase GCN5 and regulates grain weight in wheat.
Article in The Plant cell, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Epigenetic-epitranscriptomic crosstalk through TaHAG1-TaNSUN2 coordinates thermotolerance in wheat.Nature communications · 2026Article
- Direct and high-yield chromatin isolation by SBCP unlocks superior plant proteomics and epigenomic profiling.Plant cell reports · 2026Article
- Identification of CAMTA transcription factors and functional analysis of OsCAMTA4 in rice blast and salt stress.Planta · 2026Article
- Transcriptional adapter ADA2 regulates yield and end-use quality through liquid-liquid phase separation in wheat.Journal of integrative plant biology · 2026Article
- Mind the size: LARGE3-OsHDT1 complex keeps rice grain size in line.The Plant cell · 2026Article
- The Transcription Factor FgSge1 Harnesses the SAGA Complex to Activate Mycotoxin Biosynthesis and Fungal Virulence.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- The Plant Sucrose Synthase Gene Family: Multi-Level Regulatory Networks and Functional Diversification in Plants.Biomolecules · 2026Review
- LOX-A4 shapes Triticum urartu gene pools and contributions to the A subgenome of polyploid wheat.Nature communications · 2026Article
- Altered starch composition and improved bread quality in novel wheat mutant reveal key transcriptional regulators.Current research in food science · 2026Article
- Integrated Multi-Omics Reveals the Molecular Basis Underlying Wheat Grain Development and IdentifiesPlants (Basel, Switzerland) · 2025Article
- Pangenome identification and functional characterization of AHL genes in wheat (Triticum aestivum L.) reveal the role of TaAHL67 in grain weight regulation.BMC plant biology · 2025Article
- Aquilaria sinensis MYB-Like Transcription Factor AsMYB1 Promotes 2-(2-Phenylethyl)Chromone Biosynthesis Through Interacting With 14-3-3 Family Protein AsGRF1.Plant biotechnology journal · 2025Article
- Metacaspase-Peps-PEPR: The 3 musketeers in boosting wheat resistance against Fusarium head blight.The Plant cell · 2025Article
- TaSED interacts with TaSPA synergistically regulating SDS-sedimentation volume in bread wheat.Journal of integrative plant biology · 2025Article
- Calmodulin-Binding Transcription Factors: Roles in Plant Response to Abiotic Stresses.Plants (Basel, Switzerland) · 2025Review
- TaDL interacts with TaB3 and TaNF-YB1 to synergistically regulate the starch synthesis and grain quality in bread wheat.Journal of integrative plant biology · 2025Article
- The dynamic epigenetic atlas and its effects on instability of starch and seed storage protein quality traits in wheat (Frontiers in plant science · 2025Article
- From histone acetylation to abundance: The role of GCN5-CAMTA2 interaction in wheat grain weight.The Plant cell · 2024Article
- Epigenetic Regulation of Cotton Plant Height by Histone Acetyltransferase GhHAT11 via Hormonal Pathway Modulation.Physiologia plantarumArticle
Corrections and comments
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Authors and funding
17 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Grain weight and size are major traits targeted in breeding to improve wheat (Triticum aestivum L.) yield. Here, we find that the histone acetyltransferase GENERAL CONTROL NONDEREPRESSIBLE 5 (GCN5) physically interacts with the calmodulin-binding transcription factor CAMTA2 and regulates wheat grain size and weight. gcn5 mutant grains were smaller and contained less starch. GCN5 promoted the expression of the starch biosynthesis genes SUCROSE SYNTHASE 2 (Sus2) and STARCH-BRANCHING ENZYME Ic (SBEIc) by regulating H3K9ac and H3K14ac levels in their promoters. Moreover, immunoprecipitation followed by mass spectrometry (IP-MS) revealed that CAMTA2 physically interacts with GCN5. The CAMTA2-GCN5 complex activated Sus2 and SBEIc by directly binding to their promoters and depositing H3K9ac and H3K14ac marks during wheat endosperm development. camta2 knockout mutants exhibited similar phenotypes to gcn5 mutants, including smaller grains that contained less starch. In gcn5 mutants, transcripts of high molecular weight (HMW) Glutenin (Glu) genes were downregulated, leading to reduced HMW glutenin protein levels, gluten content, and sodium dodecyl sulfate (SDS) sedimentation volume. However, the association of GCN5 with Glu genes was independent of CAMTA2, since GCN5 enrichment on Glu promoters was unchanged in camta2 knockouts. Finally, we identified a CAMTA2-AH3 elite allele that corresponded with enhanced grain size and weight, serving as a candidate gene for breeding wheat varieties with improved grain weight.
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Registered trials
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