Evidence map›Paper›PMID 39320914›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2024

Total loss of

Muhannad Abu-Remaileh, Nicole S Persky, Yenarae Lee, David E Root, William G Kaelin

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. HIF2α negatively regulates MYCN protein levels and promotes a low-risk noradrenergic phenotype in neuroblastoma.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Muhannad Abu-RemailehDivision of Molecular and Cellular Oncology, Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215.ORCID 0000-0003-4962-3826
Nicole S PerskyBroad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142.
Yenarae LeeBroad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142.
David E RootBroad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142.ORCID 0000-0001-5122-861X
William G KaelinDivision of Molecular and Cellular Oncology, Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215.ORCID 0000-0002-0574-4856

Funding

Treating the P13-Kinase/AKTP50CA101942 · NCI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI David McDermott · 2003 to 2026
$53.4M
The von Hippel-Lindau Tumor Suppressor Gene and Kidney Cancer: Insights into Oxygen Sensing and Treating Cancers Caused by Undruggable MutationsR35CA210068 · NCI · DANA-FARBER CANCER INST · PI WILLIAM G. KAELIN · 2016 to 2026
$10.8M
HHS | NIH | National Cancer Institute (NCI) P50CA101942HHS | NIH | National Cancer Institute (NCI) R35-CA210068Howard Hughes Medical Institute N/ANCI NIH HHS P50 CA101942NCI NIH HHS R35 CA210068
6 · The paper itself

Abstract

Loss-of-function germline

Indexed as

Basic Helix-Loop-Helix ProteinsVon Hippel-Lindau Tumor Suppressor ProteinAnimalsCell Line, TumorEndothelial PAS Domain-Containing Protein 1HumansMiceNeuroendocrine TumorsParagangliomavon Hippel-Lindau DiseaseBasic Helix-Loop-Helix ProteinsEndothelial PAS Domain-Containing Protein 1VHL protein, humanVon Hippel-Lindau Tumor Suppressor Proteinhypoxianeuroblastomaparagangliomapheochromocytomavon Hippel–Lindau

Identifiers

PMID39320914
PMCPMC11459182

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.