Evidence map›Paper›PMID 39320590›Full record

ArticleEndocrine2025

Evaluation of testicular volume in males with congenital hypogonadotropic hypogonadism: a comparative analysis.

Konsam Biona Devi, Ujjwal Gorsi, Anupam Lal, Shubham Saini, Akhil Jerath, Dorendro Thingujam, Mintu Mani Baruah, Rama Walia

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Endocrine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

8 authors.

Konsam Biona DeviDepartment of Endocrinology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
Ujjwal GorsiDepartment of Radiodiagnosis, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
Anupam LalDepartment of Radiodiagnosis, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
Shubham SainiDepartment of Radiodiagnosis, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
Akhil JerathDepartment of Radiodiagnosis, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
Dorendro ThingujamDepartment of Cardiothoracic and Vascular Surgery, RIMS, Imphal, India.
Mintu Mani BaruahDepartment of Endocrinology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
Rama WaliaDepartment of Endocrinology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India. ramawaliapgimer@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionEstimating accurate testicular volume (TV) of congenital hypogonadotropic hypogonadism (CHH) individuals is challenging due to the typically small testicular size. Ultrasound (USG) emerges as a vital solution, enabling precise measurements and reproducible results. The purpose of the study was to assess the three-dimensional measurement of the testis using USG and its volume was estimated using Ellipsoid (E) and Lambert (L) formulae and compared these with the TV by Prader orchidometer (OrTV).

methodsThis is an exploratory analysis of data taken from a clinical trial conducted from May 2022 to March 2024 which included 94 testes from 47 CHH participants. The OrTVs and USGTVs were assessed at baseline and every three months till the completion of the study making a total of 348 observations. The three-dimensional measurement of the testes was noted and TVs were calculated using the above formulae.

resultsThe mean age of the participants was 25.8 ± 6.14 years with a mean height of 169.9 ± 8.42 cm and body mass index (BMI) of 22.4 ± 4.72 kg/m

conclusionThe study revealed that all CHH patients at diagnosis had OrTV < 4 ml. This corresponds to a USG TV cut-off of 1.11 ml using the Ellipsoid formula and 1.51 ml with the Lambert formula, which could serve as a USG diagnostic criterion for CHH.

Indexed as

HypogonadismTestisAdolescentAdultHumansMaleOrgan SizeUltrasonographyYoung AdultHypogonadotropic hypogonadismOrchidometerTesticular volumeUSG

Identifiers

PMID39320590

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.