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ArticleInternational ophthalmology2024

Corneal densitometry measurements comparison between anterior segment OCT and scheimpflug imaging.

Enrico Lupardi, Antonio Moramarco, Federico Cassini, Simone Febbraro, Giacomo Savini, Luigi Fontana

Registry-linked trialAbstract readComparative Study
In one paragraph

Article in International ophthalmology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06966167 (Comparison of Outcomes Between Femtosecond Laser-Assisted and Conventional Phacoemulsification in Fuchs Endothelial Corneal Dystrophy Patients With Cataracts), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06966167 recruitingnot on this mapstarted 2025, after this paper: background citation

Comparison of Outcomes Between Femtosecond Laser-Assisted and Conventional Phacoemulsification in Fuchs Endothelial Corneal Dystrophy Patients With Cataracts

TypeobservationalSponsorEye & ENT Hospital of Fudan UniversityRan2025 to 2030Enrolled120ConditionsFuchs Endothelial Corneal Dystrophy, Cataract
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Influence of Room Illumination on Corneal Densitometry.Translational vision science & technology · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Enrico LupardiIRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy. enrico.lupardi@gmail.com.ORCID http://orcid.org/0000-0002-1344-9806
Antonio MoramarcoIRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
Federico CassiniIRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
Simone FebbraroIRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
Giacomo SaviniIRCCS Bietti Foundation, Rome, Italy.
Luigi FontanaIRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo evaluate and compare the repeatability of corneal densitometry (CD) measurements obtained using both an anterior-segment optical coherence tomography (AS-OCT) device and a Scheimpflug camera system, while also assessing the level of agreement. The study also sought to investigate the correlation of CD with age, gender, and central corneal thickness (CCT) in normal eyes.

methodsCD measurements were obtained using the Casia 2 and the Pentacam AXL Wave. Data were collected on Total Corneal Densitometry and 4 concentric corneal annular areas, these are referred to as zone 1, denoting the central area, through to zone 4, designating the outermost peripheral region. Repeatability was assessed using intra-session test-retest variability, coefficient of variation (CoV), and intraclass correlation coefficient (ICC). The agreement was evaluated using Bland-Altman plots. Correlation analysis was performed between CD, age, gender, and CCT.

resultsThe study included 96 healthy volunteers. The Casia 2 demonstrated high repeatability with ICC values exceeding 0.9 in all the corneal zones and lower CoV values compared to the Pentacam AXL Wave (ranging from 1.07% to 2.25% for Casia 2 and from 1.91% to 6.89% for Pentacam).95% LoA were within ± 2 standard deviation from the average mean except from zone 1 (± 2.42).However, the measurements showed a consistent bias among all the corneal zones. CD values were positively correlated with age, except for zone 1 with the Pentacam (p = 0.083).

conclusionsThe findings suggest that the Casia 2 can be a reliable tool for assessing corneal transparency in healthy individuals, however its measurements are not interchangeable with those provided by the Pentacam. The AS-OCT device may be more sensitive in detecting subtle age-related changes in CD within the central zone.

Indexed as

CorneaDensitometryTomography, Optical CoherenceAdolescentAdultAgedAnterior Eye SegmentFemaleHealthy VolunteersHumansMaleMiddle AgedPhotographyProspective StudiesReproducibility of ResultsYoung AdultAS-OCTCorneal densitometryCorneal opacityCorneal transparencyScheimpflug Imaging

Identifiers

PMID39320570
PMCPMC11424699

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.