Evidence map›Paper›PMID 39320568›Full record

ArticleArchives of women's mental health2025

Risk of adverse infant outcomes associated with maternal mental health and substance use disorders.

Clare C Brown, J Mick Tilford, Michael Thomsen, Benjamin C Amick, Keneshia Bryant-Moore, Horacio Gomez-Acevedo, Creshelle Nash, Jennifer E Moore

Abstract read
In one paragraph

Article in Archives of women's mental health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Clare C BrownUniversity of Arkansas for Medical Sciences, Little Rock, AR, USA. ccbrown@uams.edu.ORCID 0000-0001-7149-4739
J Mick TilfordUniversity of Arkansas for Medical Sciences, Little Rock, AR, USA.
Michael ThomsenUniversity of Arkansas for Medical Sciences, Little Rock, AR, USA.
Benjamin C AmickUniversity of Arkansas for Medical Sciences, Little Rock, AR, USA.
Keneshia Bryant-MooreUniversity of Arkansas for Medical Sciences, Little Rock, AR, USA.
Horacio Gomez-AcevedoUniversity of Arkansas for Medical Sciences, Little Rock, AR, USA.
Creshelle NashArkansas Blue Cross and Blue Shield, Little Rock, AR, USA.
Jennifer E MooreInstitute for Medicaid Innovation, Washington, DC, USA.

Funding

Expanding Translational Research in ArkansasU54TR001629 · NCATS · UNIV OF ARKANSAS FOR MED SCIS · PI JAMES, LAURA P · 2017 to 2017
$3.5M
Using Artificial Intelligence to Optimize Delivery of Weight Loss TreatmentR01DK125641 · NIDDK · DREXEL UNIVERSITY · PI LAFATA, ERICA M · 2021 to 2024
$2.4M
The Impact of School Meal Delivery on Behavioral Disorders among Children in Health Disparity PopulationsR01MH133857 · NIMH · UNIV OF ARKANSAS FOR MED SCIS · PI THOMSEN, MICHAEL R. · 2023 to 2025
$1.1M
Algorithmic fairness in predictive models to eliminate disparities in adverse infant outcomes: A case for raceK01MD018072 · NIMHD · UNIV OF ARKANSAS FOR MED SCIS · PI BROWN, CLARE C · 2022 to 2025
$496k
NCATS NIH HHS U54 TR001629NCATS NIH HHS U54TR001629NIDDK NIH HHS 1R01DK125641NIDDK NIH HHS R01 DK125641NIMHD NIH HHS 1K01MD018072NIMHD NIH HHS K01 MD018072NIMH NIH HHS R01 MH133857NIMH NIH HHS R01MH133857
6 · The paper itself

Abstract

purposeThis study aimed to evaluate the association of mental health and substance use disorders on the risk of adverse infant outcomes overall and by race/ethnicity and payer.

methodsWe used birth certificates (2017-2022; n = 125,071) linked with state-wide insurance claims (2016-2022; n = 7,583,488) to assess the risk of an adverse infant outcome (i.e., prematurity [< 37 weeks gestation] or low birthweight [< 2,500 g]) associated with "any mental health" or "any substance use" disorder overall, by race/ethnicity, and by payer using diagnoses during the 9 months of pregnancy. We additionally evaluated seven specific mental health conditions and four specific substance use disorders.

resultsThe rate of having an adverse infant outcome was 13.4%. Approximately 21.5% of birthing individuals had a mental health condition, and 8.7% had a substance use disorder. We found increased adjusted risk of an adverse infant outcome associated with having a mental health condition overall (aRR: 1.28; 95%CI: 1.23-1.32) and for all racial/ethnic groups and payers. We additionally found increased risk associated with substance use disorder overall (aRR: 1.32; 95%CI: 1.25-1.40) and for White, Black, privately-covered, and Medicaid-covered individuals. There was increased risk associated with six of seven mental health and three of four substance use disorders.

conclusionsGiven the risk of adverse infant outcomes associated with mental health and substance use disorders across racial/ethnic groups and payers, our findings highlight the critical importance of policies and clinical guidelines that support early identification and treatment of a broad spectrum of mental health and substance use disorders throughout the perinatal period.

Indexed as

Mental DisordersPregnancy ComplicationsPregnancy OutcomeSubstance-Related DisordersAdultFemaleHumansInfant, Low Birth WeightInfant, NewbornMental HealthPregnancyPremature BirthRisk FactorsUnited StatesYoung AdultMental healthPerinatal healthSubstance use disorders

Identifiers

PMID39320568
PMCPMC11932945

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.