Evidence map›Paper›PMID 39320556›Full record

ArticleClinical rheumatology2024

Protein tyrosine phosphatase non-receptor type 2 (PTPN2) gene polymorphisms (rs2542151, rs7234029) in Egyptian Behçet's disease patients: a preliminary report.

Doaa H S Attia, Marwa Alkaffas, Mervat Eissa, Laila Rashed, Rasha A M Khattab, Radwa Elzanaty, Rabab A Khattab, Lamees A Samy

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Article in Clinical rheumatology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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8 authors.

Doaa H S AttiaRheumatology and Rehabilitation Department, Faculty of Medicine, Cairo University Hospitals, Saray El Manial Street, El Manial, Cairo, 11956, Egypt. doaahassan@kasralainy.edu.eg.ORCID http://orcid.org/0000-0003-1349-265X
Marwa AlkaffasMedical Biochemistry and Molecular Biology Department, Faculty of Medicine, Cairo University, Saray El Manial Street, El Manial, Cairo, 11956, Egypt.
Mervat EissaRheumatology and Rehabilitation Department, Faculty of Medicine, Cairo University Hospitals, Saray El Manial Street, El Manial, Cairo, 11956, Egypt.ORCID http://orcid.org/0000-0001-7999-3401
Laila RashedMedical Biochemistry and Molecular Biology Department, Faculty of Medicine, Cairo University, Saray El Manial Street, El Manial, Cairo, 11956, Egypt.
Rasha A M KhattabClinical and Chemical Pathology Department, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt.
Radwa ElzanatyOphthalmology Department, Faculty of Medicine, Cairo University, Saray El Manial Street, El Manial, Cairo, 11956, Egypt.ORCID http://orcid.org/0000-0001-6163-0899
Rabab A KhattabOphthalmology Department, Helwan University Student's Hospital, Cairo, Egypt.ORCID http://orcid.org/0000-0003-4765-8363
Lamees A SamyClinical and Chemical Pathology Department, Faculty of Medicine, Cairo University Hospitals, Saray El Manial Street, El Manial, Cairo, 11956, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Single nucleotide polymorphisms (SNPs) of the protein tyrosine phosphatase non-receptor type 2 (PTPN2) gene have been documented to be linked with several autoimmune disorders including Behçet's disease (BD). PTPN2 SNPs rs2542151 and rs7234029 have been assessed using real-time PCR in 96 BD patients and 50 controls matched by age and gender. Patients were categorized into groups according to the disease phenotypes and severity. A total of 94.8% of patients were males. The patients' mean age at onset was 26.1 ± 8 years. The median (IQR) disease duration was 8.5(4-13) years. No difference was observed between the patients and controls concerning the frequency of the two SNPs' different genotypes, models, and alleles. Moreover, neither disease phenotypes nor severity were associated with rs2542151 or rs7234029 SNPs. PTPN2 rs2542151 and rs7234029 SNPs do not seem to have associations with BD occurrence, phenotypes, or severity in the Egyptian patients. Key Points • PTPN2 rs2542151 and rs7234029 SNPs do not seem to have associations with BD occurrence, phenotypes, or severity in the Egyptian patients. • Further studies involving a larger sample size with variable clinical diversity are recommended to verify the results.

Indexed as

Behcet SyndromeGenetic Predisposition to DiseaseGenotypePolymorphism, Single NucleotideProtein Tyrosine Phosphatase, Non-Receptor Type 2AdultAllelesCase-Control StudiesEgyptFemaleGene FrequencyHumansMalePhenotypeSeverity of Illness IndexYoung AdultProtein Tyrosine Phosphatase, Non-Receptor Type 2PTPN2 protein, humanBehçet’s diseasePolymorphismsProtein tyrosine phosphatase non-receptor type 2PTPN2SNPs

Identifiers

PMID39320556
PMCPMC11489223

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