Evidence map›Paper›PMID 39320493›Full record

ArticleMikrochimica acta2024

Magnetic particle spray mass spectrometry for the determination of beta-blockers in plasma samples.

Elizângela Maria de Castilho Alves Morais, Tássia Venga Mendes, Estela Domingos Arnoni, Luiz Fernando Gorup, Mariana Azevedo Rosa, Ailton José Moreira, Eduardo Costa Figueiredo

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Article in Mikrochimica acta, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Elizângela Maria de Castilho Alves MoraisLaboratory of Toxicant and Drug Analyses, Faculty of Pharmaceutical Sciences, Federal University of Alfenas, Alfenas, MG, 37130-001, Brazil.
Tássia Venga MendesLaboratory of Toxicant and Drug Analyses, Faculty of Pharmaceutical Sciences, Federal University of Alfenas, Alfenas, MG, 37130-001, Brazil.
Estela Domingos ArnoniLaboratory of Toxicant and Drug Analyses, Faculty of Pharmaceutical Sciences, Federal University of Alfenas, Alfenas, MG, 37130-001, Brazil.
Luiz Fernando GorupInstitute of Chemistry, Federal University of Alfenas, Alfenas, MG, 37130-001, Brazil.
Mariana Azevedo RosaLaboratory of Toxicant and Drug Analyses, Faculty of Pharmaceutical Sciences, Federal University of Alfenas, Alfenas, MG, 37130-001, Brazil.
Ailton José MoreiraInstitute of Chemistry, São Paulo State University (UNESP), Araraquara, SP, 14800-060, Brazil.
Eduardo Costa FigueiredoLaboratory of Toxicant and Drug Analyses, Faculty of Pharmaceutical Sciences, Federal University of Alfenas, Alfenas, MG, 37130-001, Brazil. eduardo.figueiredo@unifal-mg.edu.br.ORCID http://orcid.org/0000-0002-7883-9717

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Magnetic particle spray mass spectrometry (MPS-MS), an innovative ambient ionization technique proposed by our research group, was employed to determine beta-blockers in human plasma samples. A dispersive solid phase extraction of atenolol, metoprolol, labetalol, propranolol, nadolol, and pindolol was carried out using magnetic molecularly imprinted polymer (M-MIP) particles that were attached to the tip of a metal probe, which was placed in the mass spectrometer inlet. A solvent (1% formic acid in methanol) was dispensed on the particles, and the Taylor cone was formed around them (in high voltage). The analytes were desorbed/ionized and determined by a triple quadrupole mass spectrometer. M-MIP was synthesized with oxprenolol as a pseudo-template, demonstrating good selectivity to beta-blockers compared with no-analog molecules, with an adsorption process occurring in monolayers, according to isotherm studies. Kinetic experiments indicated chemisorption as the predominant M-MIP/analyte interaction. The analytical curves were linear (R

Indexed as

Adrenergic beta-AntagonistsAdsorptionHumansLimit of DetectionMass SpectrometryMolecularly Imprinted PolymersSolid Phase ExtractionAdrenergic beta-AntagonistsMolecularly Imprinted PolymersAmbient ionizationDispersive solid phase extractionMagnetic particle spray mass spectrometryMagnetic sorbentMolecularly imprinted polymers

Identifiers

PMID39320493

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.