Evidence map›Paper›PMID 39320486›Full record

ArticleClinical oral investigations2024

Co-doped titanium dioxide nanoparticles decrease the cytotoxicity of experimental hydrogen peroxide gels for in-office tooth bleaching.

Matheus Kury, Rafael Antonio de Oliveira Ribeiro, Carlos Alberto de Souza Costa, Fernando Luís Esteban Florez, Vanessa Cavalli

Registry-linked trialAbstract read
PubMed Publisher
In one paragraph

Article in Clinical oral investigations, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06802614 (A Randomized Controlled Clinical Trial Comparing the Efficacy of Two Experimental Bleaching Gels With and Without Nanoparticles and Light Irradiation Versus Whiteness HP 35% and Whiteness HP AutoMixx 6% in Patients With A2-C4 Tooth Discolorations), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06802614 nanot yet recruitingnot on this mapstarted 2025, after this paper: background citation

A Randomized Controlled Clinical Trial Comparing the Efficacy of Two Experimental Bleaching Gels With and Without Nanoparticles and Light Irradiation Versus Whiteness HP 35% and Whiteness HP AutoMixx 6% in Patients With A2-C4 Tooth Discolorations

TypeinterventionalSponsorUniversity of OklahomaRan2025 to 2025Enrolled240ConditionsTooth Discoloration, Dentin Sensitivity, Patient SatisfactionArmsBLEACHING GEL A, 5% NF_TiO2, BLEACHING GEL B, VISIBLE LIGHT IRRADIATION, Whiteness HP 35%
3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Hyaluronic Acid-Based Bleaching Gels With NF_TiOJournal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry ... [et al.] · 2025
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Matheus KuryDepartment of Restorative Dentistry, Piracicaba Dental School, University of Campinas, 901 Limeira Avenue, Areião, Piracicaba, SP, 13414-903, Brazil.
Rafael Antonio de Oliveira RibeiroDepartment of Dental Materials and Prosthodontics, School of Dentistry, São Paulo State University (UNESP), Araraquara, SP, Brazil.
Carlos Alberto de Souza CostaDepartment of Physiology and Pathology, School of Dentistry, São Paulo State University (UNESP), Araraquara, SP, Brazil.
Fernando Luís Esteban FlorezDepartment of Restorative Sciences, Division of Dental Biomaterials, College of Dentistry, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Vanessa CavalliDepartment of Restorative Dentistry, Piracicaba Dental School, University of Campinas, 901 Limeira Avenue, Areião, Piracicaba, SP, 13414-903, Brazil. cavalli@unicamp.br.

Funding

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior Finance Code 001Fulbright Program Doctoral Dissertation Research Award 2020/21Fundação de Amparo à Pesquisa do Estado de São Paulo #2019/02393-6Fundação de Amparo à Pesquisa do Estado de São Paulo #2020/06782-4
6 · The paper itself

Abstract

objectiveTo evaluate the efficacy and cytotoxicity of experimental 6% and 35% hydrogen peroxide gels (HP6 or HP35) incorporated with titanium dioxide nanoparticles (NP) co-doped with nitrogen and fluorine and irradiated with a violet LED light (LT).

methodsBovine enamel-dentin disks adapted to artificial pulp chambers were randomly assigned to bleaching (n = 8/group): NC (negative control), NP, HP6, HP6 + LT, HP6 + NP, HP6 + NP + LT, HP35, HP35 + LT, HP35 + NP, HP35 + NP + LT, and commercial HP35 (COM). Color (ΔE

conclusionHP6 achieved significantly higher color and whiteness index changes when incorporated with nanoparticles and light-irradiated and caused lower cytotoxicity than HP35 gels. The nanoparticles significantly increased cell viability and reduced the hydrogen peroxide diffusion and oxidative stress, regardless of HP concentration. CLINICAL SIGNIFICANCE: Incorporation of co-doped titanium dioxide nanoparticles combined with violet irradiation within the HP6 gel could promote a higher perceivable and acceptable efficacy than HP6 alone, potentially reaching the optimal esthetic outcomes rendered by HP35. This approach also holds the promise of reducing cytotoxic damages and, consequently, tooth sensitivity.

Indexed as

Cell SurvivalGelsHydrogen PeroxideNanoparticlesTitaniumTooth BleachingTooth Bleaching AgentsAnimalsCattleDental EnamelDentinIn Vitro TechniquesOdontoblastsOxidative StressRandom AllocationGelsHydrogen PeroxideTitaniumtitanium dioxideTooth Bleaching AgentsHydrogen peroxideLight irradiationNanoparticlesTooth bleachingToxicity

Identifiers

PMID39320486

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.