Evidence map›Paper›PMID 39319995›Full record

ArticlePediatric transplantation2024

Optimizing Piperacillin Dosing in Pediatric Liver Transplant Recipients: A Case Series.

Ronaldo Morales Junior, Anhar Hosawi, Sonya Tang Girdwood, Min Dong, Vanessa D' Amaro Juodinis, Paschoalina Romano, Pérsio de Almeida Rezende Ebner, Nilo José Coelho Duarte, Daniela Carla de Souza, Silvia Regina Cavani Jorge Santos

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In one paragraph

Article in Pediatric transplantation, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ronaldo Morales JuniorClinical Pharmacokinetics Center, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, São Paulo, Brazil.ORCID 0000-0002-5856-3717
Anhar HosawiDivision of Translational and Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.ORCID 0000-0002-0350-1965
Sonya Tang GirdwoodDivision of Translational and Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.ORCID 0000-0001-7737-8499
Min DongDivision of Translational and Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.ORCID 0000-0002-8552-8298
Vanessa D' Amaro JuodinisPediatric Unit, Hospital Sírio-libanês, São Paulo, São Paulo, Brazil.ORCID 0000-0003-4749-3052
Paschoalina RomanoCentral Laboratory Division and Medical Investigation Laboratory, Medical School, University of Sao Paulo, São Paulo, São Paulo, Brazil.ORCID 0000-0003-1484-4792
Pérsio de Almeida Rezende EbnerCentral Laboratory Division and Medical Investigation Laboratory, Medical School, University of Sao Paulo, São Paulo, São Paulo, Brazil.ORCID 0000-0002-6244-8164
Nilo José Coelho DuarteCentral Laboratory Division and Medical Investigation Laboratory, Medical School, University of Sao Paulo, São Paulo, São Paulo, Brazil.ORCID 0000-0002-6525-2044
Daniela Carla de SouzaPediatric Unit, Hospital Sírio-libanês, São Paulo, São Paulo, Brazil.ORCID 0000-0002-1968-6773
Silvia Regina Cavani Jorge SantosClinical Pharmacokinetics Center, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, São Paulo, Brazil.ORCID 0000-0001-5295-2079

Funding

Antibiotic Model-Informed Precision Dosing in Critical IllnessR35GM146701 · NIGMS · CINCINNATI CHILDRENS HOSP MED CTR · PI Sonya C Tang Girdwood · 2022 to 2026
$2.0M
NIGMS NIH HHS R35GM14670NIGMS NIH HHS R35 GM146701
6 · The paper itself

Abstract

backgroundPathophysiological changes post-liver transplantation impact the pharmacokinetics and pharmacodynamics of antibiotics. Piperacillin, often used in combination with tazobactam, is a key antibiotic after transplantation to its broad-spectrum activity, but there is a lack of specific pharmacokinetic data in this population. This study aims to describe the pharmacokinetic parameters and target attainment of piperacillin in pediatric liver transplant recipients.

methodsPatients with preserved renal function (estimated glomerular filtration rate > 50 mL/min/1.73 m

resultsEight patients with median age of 8 months were included. Median piperacillin clearance and central volume of distribution for the cohort were 11.11 L/h/70 kg and 9.80 L/70 kg, respectively. Seven patients (87.5%) presented with concentrations below the target of 100% fT > MIC. Simulations suggested that these patients required more frequent dosing and extended duration of infusion to ensure target attainment. One patient (12.5%) had trough concentrations that exceed 16 mg/L and could receive a lower daily dose.

conclusionsThis case series highlights the importance of personalized therapy in pediatric liver transplant recipients due to the unpredictable and highly variable piperacillin pharmacokinetics in this population.

Indexed as

Anti-Bacterial AgentsLiver TransplantationPiperacillinPiperacillin, Tazobactam Drug CombinationBayes TheoremChildChild, PreschoolFemaleHumansInfantMaleAnti-Bacterial AgentsPiperacillinPiperacillin, Tazobactam Drug CombinationBayesian approachbeta‐lactamliver transplantationprecision dosing

Identifiers

PMID39319995
PMCPMC11433544

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.