Evidence map›Paper›PMID 39319957›Full record

ArticleEinstein (Sao Paulo, Brazil)2024

Blood concentrations of α-Klotho and FGF-23 exhibit no correlation with bone mineral density in elderly individuals.

Karina Moura Sawada, Niele Silva de Moraes, Lara Miguel Quirino Araújo, Fernanda Martins Gazoni, Marise Lazaretti-Castro, Maysa Seabra Cendoroglo, John P Bilezikian, Maria Stella Figueiredo, Fania Cristina Dos Santos

Abstract read
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In one paragraph

Article in Einstein (Sao Paulo, Brazil), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Karina Moura SawadaDiscipline of Geriatrics, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brazil.ORCID http://orcid.org/0000-0001-5847-7520
Niele Silva de MoraesDiscipline of Geriatrics, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brazil.ORCID http://orcid.org/0000-0002-9222-2908
Lara Miguel Quirino AraújoDiscipline of Geriatrics, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brazil.ORCID http://orcid.org/0000-0002-3562-373X
Fernanda Martins GazoniDiscipline of Geriatrics, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brazil.ORCID http://orcid.org/0000-0002-1214-4330
Marise Lazaretti-CastroDiscipline of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brazil.ORCID http://orcid.org/0000-0001-9186-2834
Maysa Seabra CendorogloDiscipline of Geriatrics, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brazil.ORCID http://orcid.org/0000-0003-2548-2619
John P BilezikianDivision of Endocrinology, Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York.ORCID http://orcid.org/0000-0002-1570-2617
Maria Stella FigueiredoDiscipline of Hematology and Hemotherapy, Department of Clinical and Experimental Oncology, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brazil.ORCID http://orcid.org/0000-0003-3977-9915
Fania Cristina Dos SantosDiscipline of Geriatrics, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brazil.ORCID http://orcid.org/0000-0003-2689-3532

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigating the relationship between α-Klotho and FGF-23 with bone biochemical markers and bone density findings in extremely aged individuals.

methodsA total of 55 individuals with a mean age of 85.6 years were subjected to clinical, biochemical, and bone mineral density analyses and the enzyme-linked immunosorbent assay-based detection of α-Klotho and FGF-23. The mean, standard deviation, median, and interquartile ranges of the sample values were determined, and Spearman's test for association assessments was used for statistical analysis.

resultsThe study participants expressed median FGF-23 and α-Klotho levels of 69.81 RU/mL (51.43 RU/mL) and 733.43 pg/mL (360.83 pg/mL), respectively. The majority of the participants possessed osteopenia (54.5%) and a vitamin D deficiency (57%). The 25-hydroxyvitamin D concentrations ranged between 7.1 and 47.5ng/mL, with a median of 18.1ng/mL.

conclusionNo substantial associations were discovered between α-Klotho and FGF-23 levels and bone density in the study participants.

Indexed as

BiomarkersBone DensityBone Diseases, MetabolicEnzyme-Linked Immunosorbent AssayFibroblast Growth Factor-23Fibroblast Growth FactorsGlucuronidaseKlotho ProteinsAgedAged, 80 and overFemaleHumansMaleReference ValuesVitamin DVitamin D Deficiency25-hydroxyvitamin DBiomarkersFGF23 protein, humanFibroblast Growth Factor-23Fibroblast Growth FactorsGlucuronidaseKlotho ProteinsVitamin D

Identifiers

PMID39319957
PMCPMC11461005

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.