Evidence map›Paper›PMID 39319904›Full record

Trial reportJournal of applied oral science : revista FOB2024

The effect of calcium hydroxide and double antibiotic paste on radiographic outcomes and periapical MMP-8 levels in regenerative endodontic procedures: a randomized clinical trial.

Burc Pekpinarli, Mehmet Emin Kaval, Dilsah Cogulu, Betul Ilhan, Timo Sorsa, Taina Tervahartiala, Ozant Oncag

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of applied oral science : revista FOB, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05581706 (The Effects of Calcium Hydroxide and Double Antibiotic Paste on Radiographic Outcomes and Periapical MMP-8 Levels in Regenerative Endodontic Procedures), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05581706 nacompletednot on this map

The Effects of Calcium Hydroxide and Double Antibiotic Paste on Radiographic Outcomes and Periapical MMP-8 Levels in Regenerative Endodontic Procedures: A Randomized Clinical Trial

TypeinterventionalSponsorEge UniversityRan2017 to 2021Enrolled23ConditionsRegenerative EndodonticsArmsPlace the freshly prepared calcium hydroxide in to the root canals, Place the freshly prepared double antibiotic paste in to the root canals, Taking standart periapical radiography with film holder, Sample collection for immunofluorometric assay
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Burc PekpinarliEge University, Faculty of Dentistry, Department of Pediatric Dentistry, Izmir, Turkey.ORCID http://orcid.org/0000-0002-9048-9131
Mehmet Emin KavalEge University, Faculty of Dentistry, Department of Endodontology, Izmir, Turkey.ORCID http://orcid.org/0000-0003-2388-2846
Dilsah CoguluEge University, Faculty of Dentistry, Department of Pediatric Dentistry, Izmir, Turkey.
Betul IlhanEge University, Faculty of Dentistry, Department of Oral and Maxillofacial Radiology, Izmir, Turkey.
Timo SorsaUniversity of Helsinki, Institute of Dentistry, Helsinki University Central Hospital (HUCH), Department of Oral and Maxillofacial Diseases, Helsinki, Finland.
Taina TervahartialaUniversity of Helsinki, Institute of Dentistry, Helsinki University Central Hospital (HUCH), Department of Oral and Maxillofacial Diseases, Helsinki, Finland.
Ozant OncagEge University, Faculty of Dentistry, Department of Pediatric Dentistry, Izmir, Turkey.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe primary goal is to evaluate the effects of two different intracanal medicaments, calcium hydroxide [Ca(OH)2] and double antibiotic paste (DAP), on radiographic outcomes during regenerative endodontic procedures (REP) of immature permanent mandibular first molars with symptomatic irreversible pulpitis and symptomatic apical periodontitis (SIP/SAP). Additionally, the secondary goal was to evaluate MMP-8 levels during REP using two different intracanal medicaments. METHODOLOGY: The study included 20 patients with immature mandibular first molars exhibiting SIP/SAP. Participants were randomly assigned into two groups based on the applied intracanal medicament. Ca(OH)2 (n=10) was prepared by mixing it with sterile distilled water, while the same amount of powdered metronidazole and ciprofloxacin were mixed and combined with sterile distilled water for DAP (n=10). MMP-8 in periapical samples were measured at baseline and on the 14th day using immunofluorometric assay. Image-J software with TurboReg plug-in was utilized to determine changes in root length, root width, radiographic root area (RRA) during the 12-month follow-up period. Data were analyzed by SPSS 25.0 (p<.05).

resultsSignificant increase in MMP-8 on the 14th day compared to baseline in both groups (p<0.001). There was no significant difference between the two groups in terms of the increase in MMP-8 (p>0.05). Root length significantly increased in both groups (p=0.001), with Ca(OH)2 showing a greater increase (p=0.046). Root width and RRA increased similarly in both groups at 12th month.

conclusionBoth Ca(OH)2 and DAP applications resulted in a significant increase in periapical MMP-8 levels. Increase in radiographic root width and root area was similar between two groups, but Ca(OH)2 led to a significantly greater increase in root length. Further studies with larger sample sizes are necessary to validate our findings during REP of vital immature permanent mandibular molars. Clinical Trials database: NCT05581706.

Indexed as

Anti-Bacterial AgentsCalcium HydroxideCiprofloxacinMatrix Metalloproteinase 8MetronidazolePeriapical PeriodontitisRegenerative EndodonticsRoot Canal IrrigantsAdolescentChildFemaleHumansMaleMolarPulpitisReference ValuesAnti-Bacterial AgentsCalcium HydroxideCiprofloxacinMatrix Metalloproteinase 8MetronidazoleRoot Canal Irrigants

Identifiers

PMID39319904
PMCPMC11464082

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.