ArticleMemorias do Instituto Oswaldo Cruz2024
Description of the new HIV-1 intersubtype B/C circulating recombinant form (CRF146_BC) detected in Brazil.
Article in Memorias do Instituto Oswaldo Cruz, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Article
- Molecular analysis of multiple HIV-1 BC recombinant strains circulating worldwide shows predominance of the C genotype in the viral genomic structure.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2025Article
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7 authors.
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Abstract
backgroundThe human immunodeficiency virus 1 (HIV-1) infections in Brazil are predominantly caused by two subtypes, B and C.
objectivesHere we present the characterisation of a novel HIV-1 recombinant form, indicating a new Brazilian CRF_BC, named CRF146_BC.
methodsRDP, JphMM and Simplot recombination tools were used to evaluate the mosaic pattern.
findingsIn this work, we identified three HIV-1 nucleotide sequences previously classified as unique recombinant forms (URFs), plus one new partial genome sharing the same BC recombination pattern. The mosaic genome is almost entirely represented by the subtype C sequence, with a small subtype B recombination region in the pol gene, at the Integrase level. The phylogenetic analyses strongly indicate a common origin between the strains, which were isolated in Rio Grande do Sul, Rio de Janeiro and Bahia states. MAIN
conclusionsThus, the new HIV-1 CRF146_BC is circulating in three different Brazilian regions: South, Southeast and Northeast.
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