Evidence map›Paper›PMID 39319784›Full record

ArticleJournal of neurophysiology2024

Pairing tones with vagus nerve stimulation improves brain stem responses to speech in the valproic acid model of autism.

Yuko Tamaoki, Varun Pasapula, Tanya T Danaphongse, Alfonso R Reyes, Collin R Chandler, Michael S Borland, Jonathan R Riley, Alan M Carroll, Crystal T Engineer

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurophysiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yuko TamaokiTexas Biomedical Device Center, The University of Texas at Dallas, Richardson, Texas, United States.ORCID 0000-0002-5102-9167
Varun PasapulaTexas Biomedical Device Center, The University of Texas at Dallas, Richardson, Texas, United States.
Tanya T DanaphongseTexas Biomedical Device Center, The University of Texas at Dallas, Richardson, Texas, United States.ORCID 0000-0003-2125-2082
Alfonso R ReyesTexas Biomedical Device Center, The University of Texas at Dallas, Richardson, Texas, United States.
Collin R ChandlerTexas Biomedical Device Center, The University of Texas at Dallas, Richardson, Texas, United States.ORCID 0000-0002-9375-990X
Michael S BorlandTexas Biomedical Device Center, The University of Texas at Dallas, Richardson, Texas, United States.ORCID 0000-0002-0901-4965
Jonathan R RileyTexas Biomedical Device Center, The University of Texas at Dallas, Richardson, Texas, United States.ORCID 0000-0003-0129-3071
Alan M CarrollTexas Biomedical Device Center, The University of Texas at Dallas, Richardson, Texas, United States.ORCID 0000-0002-9917-6350
Crystal T EngineerTexas Biomedical Device Center, The University of Texas at Dallas, Richardson, Texas, United States.ORCID 0000-0002-2188-2335

Funding

Enhancing Speech Processing In A Rat Model Of Autism Using Vagus Nerve StimulationR01DC017480 · NIDCD · UNIVERSITY OF TEXAS DALLAS · PI ENGINEER, CRYSTAL T · 2019 to 2023
$2.0M
HHS | National Institutes of Health (NIH) R01DC017480NIDCD NIH HHS R01 DC017480
6 · The paper itself

Abstract

Receptive language deficits and aberrant auditory processing are often observed in individuals with autism spectrum disorders (ASD). Symptoms associated with ASD are observed in rodents prenatally exposed to valproic acid (VPA), including deficits in speech sound discrimination ability. These perceptual difficulties are accompanied by changes in neural activity patterns. In both cortical and subcortical levels of the auditory pathway, VPA-exposed rats have impaired responses to speech sounds. Developing a method to improve these neural deficits throughout the auditory pathway is necessary. The purpose of this study was to investigate the ability of vagus nerve stimulation (VNS) paired with sounds to restore degraded inferior colliculus (IC) responses in VPA-exposed rats. VNS paired with the speech sound "dad" was presented to a group of VPA-exposed rats 300 times per day for 20 days. Another group of VPA-exposed rats were presented with VNS paired with multiple tone frequencies for 20 days. The IC responses were recorded from 19 saline-exposed control rats and 18 VPA-exposed with no VNS, 8 VNS-speech paired VPA-exposed, and 7 VNS-tone paired VPA-exposed female and male rats. Pairing VNS with tones increased the IC response strength to speech sounds by 44% compared to VPA-exposed rats alone. Contrarily, VNS-speech pairing significantly decreased the IC response to speech compared with VPA-exposed rats by 5%. The present research indicates that pairing VNS with tones improved sound processing in rats exposed to VPA and suggests that auditory processing can be improved through targeted plasticity.

Indexed as

Disease Models, AnimalVagus Nerve StimulationValproic AcidAcoustic StimulationAnimalsAutism Spectrum DisorderAutistic DisorderEvoked Potentials, Auditory, Brain StemFemaleInferior ColliculiMalePregnancyRatsRats, Sprague-DawleySpeech PerceptionValproic Acidautism spectrum disorderinferior colliculusplasticityvagus nerve stimulationvalproic acid

Identifiers

PMID39319784
PMCPMC11573256

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.