Evidence map›Paper›PMID 39319663›Full record

ArticleAnalytical chemistry2024

Insights into the Main Protease of SARS-CoV-2: Thermodynamic Analysis, Structural Characterization, and the Impact of Inhibitors.

Jamie P Butalewicz, Sarah N Sipe, Kyle J Juetten, Virginia K James, Kangsan Kim, Y Jessie Zhang, Thomas D Meek, Jennifer S Brodbelt

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Analytical chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jamie P ButalewiczDepartment of Chemistry, The University of Texas at Austin, Austin, Texas 78712, United States.
Sarah N SipeDepartment of Chemistry, The University of Texas at Austin, Austin, Texas 78712, United States.
Kyle J JuettenDepartment of Chemistry, The University of Texas at Austin, Austin, Texas 78712, United States.
Virginia K JamesDepartment of Chemistry, The University of Texas at Austin, Austin, Texas 78712, United States.
Kangsan KimDepartment of Molecular Biosciences, The University of Texas at Austin, Austin, Texas 78712, United States.
Y Jessie ZhangDepartment of Molecular Biosciences, The University of Texas at Austin, Austin, Texas 78712, United States.ORCID 0000-0002-9360-5388
Thomas D MeekDepartment of Biochemistry and Biophysics, Texas A&M University, College Station, Texas 77843, United States.ORCID 0000-0002-1931-8073
Jennifer S BrodbeltDepartment of Chemistry, The University of Texas at Austin, Austin, Texas 78712, United States.ORCID 0000-0003-3207-0217

Funding

Ultraviolet Photodissociation Mass Spectrometry for Characterization of Biological MoleculesR35GM139658 · NIGMS · UNIVERSITY OF TEXAS AT AUSTIN · PI BRODBELT, JENNIFER S. · 2021 to 2025
$2.9M
Deciphering the phosphorylation pattern of RNA polymerase II for eukaryotic transcriptionR35GM148356 · NIGMS · UNIVERSITY OF TEXAS AT AUSTIN · PI Yan Jessie Zhang · 2023 to 2026
$2.3M
NIGMS NIH HHS R35 GM139658NIGMS NIH HHS R35 GM148356
6 · The paper itself

Abstract

The main protease (M

Indexed as

Coronavirus 3C ProteasesProtease InhibitorsSARS-CoV-2ThermodynamicsAntiviral AgentsCOVID-19COVID-19 Drug TreatmentHumansAntiviral AgentsCoronavirus 3C ProteasesProtease Inhibitors

Identifiers

PMID39319663
PMCPMC11499983

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.