SynthesisJournal of periodontal research2025
Do all individuals benefit equally from non-surgical periodontal therapy? Secondary analyses of systematic review data.
Synthesis in Journal of periodontal research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Do all individuals benefit equally from non-surgical periodontal therapy? Secondary analyses of systematic review data.Journal of periodontal research · 2025Pooled it
- Non-Surgical Periodontal Defect Fill and Spontaneous Tooth Repositioning: A Case Report.Reports (MDPI) · 2026Article
- Dose-dependent association of systemic comorbidities with periodontitis severity: A large population cross-sectional study.Journal of periodontology · 2026Observational
- Association of Periodontal Condition With Serum C-Reactive Protein Levels: The Role of Serum Apolipoproteins' Concentration.Journal of clinical periodontology · 2025Article
- Propolis as an Adjunct in Non-Surgical Periodontal Therapy: Current Clinical Perspectives from a Narrative Review.Journal of functional biomaterials · 2025Review
- Surgical Versus Non-Surgical Treatment of Periodontitis: The Past, the Present, the Future.Journal of periodontal research · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsThis study aimed to assess the variability and treatment effect heterogeneity in response to non-surgical periodontal therapy (NSPT).
methodsData from randomized controlled trials included in two recent systematic reviews on the effect of NSPT on mean clinical attachment loss (CAL), mean probing pocket depth (PPD), percentage of sites with bleeding on probing (%BOP), PPD ≤3 mm (%PD ≤3 mm), and C-reactive protein levels (CRP) at 3-12-month follow-up among adults with systemic diseases or conditions were used. In these trials, the control arms received no treatment, hygiene advice, or supragingival scaling. The Bayesian meta-regression models were utilized to assess the variability ratios between NSPT and control groups.
resultsData from 36 trials on mean PPD, 32 trials on mean CAL, eight trials on %PD ≤3 mm, 31 trials on %BOP and 19 trials on CRP were used. Variability in mean CAL and CRP was approximately 10% higher in the NSPT arms than in the control arms, hinting that there may be room for treatment effect heterogeneity. Instead, variability in mean PPD, %BOP, and %PD ≤3 mm was lower in the NSPT arms than in the control arms.
conclusionPotential treatment effect heterogeneity in response to NSPT was observed for CRP and mean CAL. However, substantial measurement error in CAL and natural variation in CRP may contribute to these findings. Conversely, treatment effect heterogeneity appears less pronounced for mean PPD, %BOP, and %PD ≤3 mm, potentially due to greater treatment effects in patients with more severe periodontitis and reduced measurement error in these parameters.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.