Evidence map›Paper›PMID 39319450›Full record

Trial reportCirculation2024

Effect of Delayed Remote Ischemic Preconditioning on Acute Kidney Injury and Outcomes in Patients Undergoing Cardiac Surgery: A Randomized Clinical Trial.

Ping Jia, Qiang Ji, Zhouping Zou, Qi Zeng, Ting Ren, Weize Chen, Zhixin Yan, Daoqi Shen, Yang Li, Fangyuan Peng and 6 more

3 registry-linked trialsAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Circulation, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06707350 nanot yet recruitingnot on this map

Protective Effect of Remote Ischemic Preconditioning (RIPC) Against Negative Inflammatory Response and Organ Dysfunction After Cardiovascular Surgery (Panda VII)

TypeinterventionalSponsorNanjing Medical UniversityRan2024 to 2025Enrolled500ConditionsCardiopulmonary Bypass, Cardiovascular Diseases, Inflammatory Response During Cardiac SurgeryArmsRemote ischemic preconditioning (RIPC), sham condition (control group)
NCT07617675 phase4not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Perioperative Recombinant Human Brain Natriuretic Peptide for Renal Protection in Cardiac Surgery: the PROTECT-CS Randomized Clinical Trial

TypeinterventionalSponsorChina National Center for Cardiovascular DiseasesRan2026 to 2029Enrolled694ConditionsAKI - Acute Kidney Injury, Cardiac Surgical Procedures, Cardiopulmonary BypassArmsRecombinant Human Brain Natriuretic Peptide (rhBNP), Normal Saline (Placebo)
NCT07746102 narecruitingnot on this mapstarted 2026, after this paper: background citation

Assessment of the Impact of Repeated Ischemic Preconditioning Episodes on Hemodynamic and Metabolic Parameters in Patients at Various Stages of Chronic Kidney Disease

TypeinterventionalSponsorMedical University of LodzRan2026 to 2026Enrolled60ConditionsHemodialysis, Ischemia Preconditioning, Chronic Kidney Disease, Blood Pressure DisordersArmsPreconditioning with control ischemic episodes
3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Ping Jia *Department of Nephrology, Zhongshan Hospital, Fudan University, and Shanghai Medical Center of Kidney, and Shanghai Key Laboratory of Kidney and Blood Purification, China (P.J., Z.Z., Q.Z., T.R., W.C., Z.Y., D.S., Y.L., F.P., B.S., J.X., X.D.).ORCID 0000-0002-0608-161X
Qiang Ji *Department of Cardiovascular Surgery (Q.J., C.W.), Zhongshan Hospital, Fudan University, Shanghai.
Zhouping ZouDepartment of Nephrology, Zhongshan Hospital, Fudan University, and Shanghai Medical Center of Kidney, and Shanghai Key Laboratory of Kidney and Blood Purification, China (P.J., Z.Z., Q.Z., T.R., W.C., Z.Y., D.S., Y.L., F.P., B.S., J.X., X.D.).ORCID 0000-0001-5835-3405
Qi ZengDepartment of Nephrology, Zhongshan Hospital, Fudan University, and Shanghai Medical Center of Kidney, and Shanghai Key Laboratory of Kidney and Blood Purification, China (P.J., Z.Z., Q.Z., T.R., W.C., Z.Y., D.S., Y.L., F.P., B.S., J.X., X.D.).
Ting RenDepartment of Nephrology, Zhongshan Hospital, Fudan University, and Shanghai Medical Center of Kidney, and Shanghai Key Laboratory of Kidney and Blood Purification, China (P.J., Z.Z., Q.Z., T.R., W.C., Z.Y., D.S., Y.L., F.P., B.S., J.X., X.D.).ORCID 0000-0002-2191-0711
Weize ChenDepartment of Nephrology, Zhongshan Hospital, Fudan University, and Shanghai Medical Center of Kidney, and Shanghai Key Laboratory of Kidney and Blood Purification, China (P.J., Z.Z., Q.Z., T.R., W.C., Z.Y., D.S., Y.L., F.P., B.S., J.X., X.D.).ORCID 0000-0002-7198-2027
Zhixin YanDepartment of Nephrology, Zhongshan Hospital, Fudan University, and Shanghai Medical Center of Kidney, and Shanghai Key Laboratory of Kidney and Blood Purification, China (P.J., Z.Z., Q.Z., T.R., W.C., Z.Y., D.S., Y.L., F.P., B.S., J.X., X.D.).
Daoqi ShenDepartment of Nephrology, Zhongshan Hospital, Fudan University, and Shanghai Medical Center of Kidney, and Shanghai Key Laboratory of Kidney and Blood Purification, China (P.J., Z.Z., Q.Z., T.R., W.C., Z.Y., D.S., Y.L., F.P., B.S., J.X., X.D.).
Yang LiDepartment of Nephrology, Zhongshan Hospital, Fudan University, and Shanghai Medical Center of Kidney, and Shanghai Key Laboratory of Kidney and Blood Purification, China (P.J., Z.Z., Q.Z., T.R., W.C., Z.Y., D.S., Y.L., F.P., B.S., J.X., X.D.).
Fangyuan PengDepartment of Nephrology, Zhongshan Hospital, Fudan University, and Shanghai Medical Center of Kidney, and Shanghai Key Laboratory of Kidney and Blood Purification, China (P.J., Z.Z., Q.Z., T.R., W.C., Z.Y., D.S., Y.L., F.P., B.S., J.X., X.D.).ORCID 0009-0000-2619-0293
Ying SuCardiac Intensive Care Center (Y.S., Z.L.), Zhongshan Hospital, Fudan University, Shanghai.ORCID 0000-0001-8355-4903
Jiarui XuDepartment of Nephrology, Zhongshan Hospital, Fudan University, and Shanghai Medical Center of Kidney, and Shanghai Key Laboratory of Kidney and Blood Purification, China (P.J., Z.Z., Q.Z., T.R., W.C., Z.Y., D.S., Y.L., F.P., B.S., J.X., X.D.).ORCID 0000-0003-4925-2770
Bo ShenDepartment of Nephrology, Zhongshan Hospital, Fudan University, and Shanghai Medical Center of Kidney, and Shanghai Key Laboratory of Kidney and Blood Purification, China (P.J., Z.Z., Q.Z., T.R., W.C., Z.Y., D.S., Y.L., F.P., B.S., J.X., X.D.).
Zhe LuoCardiac Intensive Care Center (Y.S., Z.L.), Zhongshan Hospital, Fudan University, Shanghai.
Chunsheng WangDepartment of Cardiovascular Surgery (Q.J., C.W.), Zhongshan Hospital, Fudan University, Shanghai.ORCID 0009-0008-4582-5897
Xiaoqiang DingDepartment of Nephrology, Zhongshan Hospital, Fudan University, and Shanghai Medical Center of Kidney, and Shanghai Key Laboratory of Kidney and Blood Purification, China (P.J., Z.Z., Q.Z., T.R., W.C., Z.Y., D.S., Y.L., F.P., B.S., J.X., X.D.).ORCID 0000-0003-4954-8539

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRemote ischemic preconditioning (RIPC) has 2 time windows for organ protection: acute and delayed. Previous studies have mainly focused on the organoprotective effects of acute RIPC. We aimed to determine whether delayed RIPC can reduce the occurrence of acute kidney injury (AKI) and postoperative complications in patients undergoing cardiac surgery.

methodsThis prospective, single-center, double-blind, randomized controlled trial involved 509 patients at high risk for AKI who were scheduled for elective cardiac surgery requiring cardiopulmonary bypass. Patients were randomized to receive RIPC (4 cycles of 5-minute inflation and 5-minute deflation on 1 upper arm with a blood pressure cuff) 24 hours before surgery or a sham condition (control group) that was induced by 4 cycles of 5-minute inflation to a pressure of 20 mm Hg followed by 5-minute cuff deflation. The primary end point was the incidence of AKI within the prior 7 days after cardiac surgery. The secondary end points included renal replacement therapy during hospitalization, change in urinary biomarkers of AKI and markers of myocardial injury, duration of intensive care unit stay and mechanical ventilation, and occurrence of nonfatal myocardial infarction, stroke, and all-cause mortality by day 90.

resultsA total of 509 patients (mean age, 65.2±8.2 years; 348 men [68.4%]) were randomly assigned to the RIPC group (n=254) or control group (n=255). AKI was significantly reduced in the RIPC group compared with the control group (69/254 [27.2%] versus 90/255 [35.3%]; odds ratio, 0.68 [95% CI, 0.47-1.00];

conclusionsAmong high-risk patients undergoing cardiac surgery, delayed RIPC significantly reduced the occurrence of AKI. REGISTRATION: URL: https://www.chictr.org.cn; Unique identifier: ChiCTR2000035568.

Indexed as

Acute Kidney InjuryCardiac Surgical ProceduresIschemic PreconditioningAgedBiomarkersCardiopulmonary BypassDouble-Blind MethodFemaleHumansMaleMiddle AgedPostoperative ComplicationsProspective StudiesTime FactorsTreatment OutcomeBiomarkersacute kidney injurybiomarkerscardiac surgical proceduresischemic preconditioning

Identifiers

PMID39319450
PMCPMC11495536

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.