Evidence map›Paper›PMID 39319343›Full record

ArticleToxicology research2024

Effective paclitaxel:

Sautan Show, Debanjan Dutta, Upendra Nongthomba, Mahadesh Prasad A J

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxicology research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Sautan ShowDepartment of Biochemistry, Pooja Bhagavat Memorial Mahajana Postgraduate Centre, K.R.S. Road, Metagalli, Mysore 570016, India.ORCID https://orcid.org/0000-0002-6470-3114
Debanjan DuttaDepartment of Developmental Biology and Genetics, Indian Institute of Science, CV Raman Rd, Bengaluru 560012, India.ORCID https://orcid.org/0000-0003-1608-6921
Upendra NongthombaDepartment of Developmental Biology and Genetics, Indian Institute of Science, CV Raman Rd, Bengaluru 560012, India.ORCID https://orcid.org/0000-0002-0616-5995
Mahadesh Prasad A JDepartment of Biochemistry, Pooja Bhagavat Memorial Mahajana Postgraduate Centre, K.R.S. Road, Metagalli, Mysore 570016, India.ORCID https://orcid.org/0000-0002-5792-6600

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Paclitaxel (PCTX) is one of the most prevalently used chemotherapeutic agents. However, its use is currently beset with a host of problems: solubility issue, microplastic leaching, and drug resistance. Since drug discovery is challenging, we decided to focus on repurposing the drug itself by remedying its drawbacks and making it more effective. In this study, we have harnessed the aqueous solubility of sugars, and the high affinity of cancer cells for them, to entrap the hydrophobic PCTX within the hydrophilic shell of the carbohydrate

Indexed as

AntineoplasmCell cultureCyclodextrinElectron microscopyPaclitaxelZebrafish

Identifiers

PMID39319343
PMCPMC11417963

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.