Evidence map›Paper›PMID 39319326›Full record

ArticlePNAS nexus2024

Death-associated protein kinase 3 modulates migration and invasion of triple-negative breast cancer cells.

Junkai Wang, Anh M Tran-Huynh, Beom-Jun Kim, Doug W Chan, Matthew V Holt, Diana Fandino, Xin Yu, Xiaoli Qi, Jin Wang, Weijie Zhang and 7 more

Abstract read
In one paragraph

Article in PNAS nexus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Junkai WangLester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA.ORCID https://orcid.org/0000-0003-4782-5790
Anh M Tran-HuynhLester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA.
Beom-Jun KimLester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA.
Doug W ChanLester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA.
Matthew V HoltLester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA.
Diana FandinoLester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA.
Xin YuVerna and Marrs McLean Department of Biochemistry and Molecular Pharmacology, Baylor College of Medicine, Houston, TX 77030, USA.ORCID https://orcid.org/0000-0003-1986-9040
Xiaoli QiVerna and Marrs McLean Department of Biochemistry and Molecular Pharmacology, Baylor College of Medicine, Houston, TX 77030, USA.
Jin WangVerna and Marrs McLean Department of Biochemistry and Molecular Pharmacology, Baylor College of Medicine, Houston, TX 77030, USA.ORCID https://orcid.org/0000-0003-3625-7919
Weijie ZhangLester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA.ORCID https://orcid.org/0000-0002-6462-6067
Yi-Hsuan WuLester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA.
Meenakshi AnuragLester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA.
Xiang H F ZhangLester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA.ORCID https://orcid.org/0000-0002-5674-8670
Bing ZhangLester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA.ORCID https://orcid.org/0000-0001-8676-2425
Chonghui ChengLester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA.
Charles E FouldsLester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA.ORCID https://orcid.org/0000-0003-4908-1473
Matthew J EllisLester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA.ORCID https://orcid.org/0000-0002-8467-8534

Funding

Tumor BiologyP30CA125123 · NCI · BAYLOR COLLEGE OF MEDICINE · PI Suzanne AW Fuqua · 2007 to 2026
$73.9M
Translational Research in Breast Cancer (SPORE)P50CA186784 · NCI · BAYLOR COLLEGE OF MEDICINE · PI MATTHEW J ELLIS · 2014 to 2026
$24.5M
MICROSCALED PROTEOGENOMICS FOR CANCER CLINICAL TRIALSU01CA214125 · NCI · BAYLOR COLLEGE OF MEDICINE · PI ANURAG, MEENAKSHI, CARR, STEVEN A · 2017 to 2021
$7.0M
iPGDAC, An Integrative Proteogenomic Data Analysis Center for CPTACU24CA210954 · NCI · BAYLOR COLLEGE OF MEDICINE · PI ZHANG, BING · 2016 to 2020
$4.9M
NCI NIH HHS P30 CA125123NCI NIH HHS P50 CA186784NCI NIH HHS U01 CA214125NCI NIH HHS U24 CA210954
6 · The paper itself

Abstract

Sixteen patient-derived xenografts (PDXs) were analyzed using a mass spectrometry (MS)-based kinase inhibitor pull-down assay (KIPA), leading to the observation that death-associated protein kinase 3 (DAPK3) is significantly and specifically overexpressed in the triple-negative breast cancer (TNBC) models. Validation studies confirmed enrichment of DAPK3 protein, in both TNBC cell lines and tumors, independent of mRNA levels. Genomic knockout of

Indexed as

DAPK3epithelial-to-mesenchymal transitioninvasionmigrationtriple-negative breast cancer

Identifiers

PMID39319326
PMCPMC11421662

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.