ReviewFrontiers in neuroscience2024
Role of stress and early-life stress in the pathogeny of inflammatory bowel disease.
Review in Frontiers in neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Varying patterns of risk factors for inflammatory bowel disease in the East and the West: insights from the global burden of disease study 2021.BMC public health · 2025Pooled it
- The Gut-Brain Axis in Neurodegeneration: Mechanistic Links Between Dysbiosis and Neuropathology.Iranian journal of pathology · 2026Review
- The Protective Effects of Chlorogenic Acid in Mitigating Gut-Brain Barrier Dysfunction and Autism-Like Symptoms Caused by Early-Life Stress in Mice: A Behavioral, Histopathological, and Molecular Study.Molecular neurobiology · 2026Article
- Blunted Cortisol Awakening Response in Patients with Inflammatory Bowel Disease: A Cross-Sectional Case-Control Study.Medical sciences (Basel, Switzerland) · 2026Article
- Childhood Trauma and Subjective Symptoms of Inflammatory Bowel Disease Health-Related Quality of Life in the General Population: The Mediating Roles of Emotional Suppression and Cognitive Control.International journal of environmental research and public health · 2026Article
- An Overview of the Rationale and Outcomes of Residential Camps for Children with Inflammatory Bowel Disease.Pediatric gastroenterology, hepatology & nutrition · 2026Review
- Adverse childhood experiences and gastrointestinal symptoms in US youth: Psychosocial pathways and protective contexts.Journal of pediatric gastroenterology and nutrition · 2026Article
- Psychological stress and eating behaviors as interacting influences on patient-reported disease activity in Italian patients with inflammatory bowel disease.Scientific reports · 2025Article
- Serum 25-Hydroxyvitamin D3 Status in Adolescents With Anxiety Disorders: A Case-Control and Vitamin D Supplementation Substudy.Brain and behavior · 2025Article
- A Heavy Feeling in the Stomach: Neural Correlates of Anxiety in Crohn's Disease.Neurogastroenterology and motility · 2025Article
- [Functional disorders in chronic inflammatory bowel disease: the gut-brain axis].Innere Medizin (Heidelberg, Germany) · 2025Review
- A Brief Historic Review of Research on Early Life Stress and Inflammation across the Lifespan.Neuroimmunomodulation · 2025Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Numerous preclinical and clinical studies have shown that stress is one of the main environmental factor playing a significant role in the pathogeny and life-course of bowel diseases. However, stressful events that occur early in life, even during the fetal life, leave different traces within the central nervous system, in area involved in stress response and autonomic network but also in emotion, cognition and memory regulation. Early-life stress can disrupt the prefrontal-amygdala circuit thus favoring an imbalance of the autonomic nervous system and the hypothalamic-pituitary adrenal axis, resulting in anxiety-like behaviors. The down regulation of vagus nerve and cholinergic anti-inflammatory pathway favors pro-inflammatory conditions. Recent data suggest that emotional abuse at early life are aggravating risk factors in inflammatory bowel disease. This review aims to unravel the mechanisms that explain the consequences of early life events and stress in the pathophysiology of inflammatory bowel disease and their mental co-morbidities. A review of therapeutic potential will also be covered.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.