Evidence map›Paper›PMID 39319280›Full record

ArticlePediatric gastroenterology, hepatology & nutrition2024

Relationship of MicroRNA according to Immune Components of Breast Milk in Korean Lactating Mothers.

You Jin Choi, Da Hye Lee, Jeonglyn Song, Ki-Uk Kim, Hyeyoung Min, Sung-Hoon Chung, Tae Hyeong Kim, Chae-Young Kim, Insoo Kang, Na Mi Lee and 1 more

Abstract read
In one paragraph

Article in Pediatric gastroenterology, hepatology & nutrition, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

You Jin ChoiDepartment of Pediatrics Inje University Ilsanpaik Hospital, Goyang, Korea.ORCID https://orcid.org/0000-0002-6882-3877
Da Hye LeeDepartment of Pediatrics, Chung-Ang University Hospital, Seoul, Korea.ORCID https://orcid.org/0000-0002-4768-4468
Jeonglyn SongChung-Ang University Industry Academic Cooperation Foundation, Seoul, Korea.ORCID https://orcid.org/0000-0002-6578-6644
Ki-Uk KimCollege of Pharmacy, Chung-Ang University, Seoul, Korea.ORCID https://orcid.org/0000-0002-0745-0675
Hyeyoung MinCollege of Pharmacy, Chung-Ang University, Seoul, Korea.ORCID https://orcid.org/0000-0002-7964-2924
Sung-Hoon ChungDepartment of Pediatrics, Kyung Hee University Hospital at Gangdong, Seoul, Korea.ORCID https://orcid.org/0000-0002-0352-9722
Tae Hyeong KimDepartment of Pediatrics, Kyung Hee University Hospital at Gangdong, Seoul, Korea.ORCID https://orcid.org/0000-0002-0243-7148
Chae-Young KimDepartment of Pediatrics, Kyung Hee University Hospital at Gangdong, Seoul, Korea.ORCID https://orcid.org/0000-0002-9905-6519
Insoo KangSection of Rheumatology, Allergy & Immunology, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA.ORCID https://orcid.org/0000-0001-7483-1171
Na Mi LeeCollege of Medicine, Chung-Ang University, Seoul, Korea.ORCID https://orcid.org/0000-0003-0580-8677
Dae Yong YiCollege of Medicine, Chung-Ang University, Seoul, Korea.ORCID https://orcid.org/0000-0002-4168-7131

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: Human breast milk (HBM) contains immune components that produced and delivered from the mother along with nutrients necessary for the baby. MicroRNA (miRNA) is a small noncoding RNA molecule, that is used as an ideal biomarker for diagnosis and prognosis of various diseases and are more abundant in HBM. We analyzed and compared the immune components and miRNAs of HBM. Methods: HBM were collected from 20 healthy breastfeeding mothers. We measured the amount of lactoferrin, lysozyme, and immunoglobulin A (IgA) and extracted the miRNAs from each breast milk samples. Next, the top 5 and bottom 5 expressed miRNAs were compared and analyzed based on the amounts of the 3 immune components. Results: The mean levels and ranges of lactoferrin, lysozyme, and IgA were 6.33 (2.24-14.77)×10 Conclusion: We identified the immune components and miRNAs in breast milk and found that each individual has different ingredients.

Indexed as

Human milkImmunoglobulin ALactoferrinLysozymeMicroRNAs

Identifiers

PMID39319280
PMCPMC11419785

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.