ArticleiScience2024
Arched microfluidic channel for the promotion of axonal growth performance.
Article in iScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Emerging Regenerative Medicine for Spinal Cord Injury: Spinal Cord Organoids-on-a-Chip.International journal of molecular sciences · 2026Review
- Roll-to-Roll (R2R) High-Throughput Manufacturing of Foil-Based Microfluidic Chips for Neurite Outgrowth Studies.Micromachines · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Uniformly distributed fluid shear stress can promote axonal growth, aiding in the efficient construction of functional neural interfaces. However, challenges remain in the construction of the micro-scale environment with a uniform fluidic stress distribution. In this study, we designed and fabricated a microfluidic chip with arched-section microfluidic channels (AMCs) to increase primary cortical neuron growth rate and terminal number by constructing a uniform-stress-distributed environment. Inspired by the three-dimensional (3D) microenvironment where cerebrospinal-fluid-contacting neurons are located, the surface curvature of the traditional rectangular-section microfluidic channel (RMC) was adjusted to construct structures with 3D curved surfaces. Compared with those on the RMC chips, the average growth rate of the axons on the AMC chips increased by 8.9% within 19 days, and the average number of terminals increased by 14.9%. This platform provides a structure that can effectively promote neuron growth and has potential in constructing more complex functional neural interfaces.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.