Evidence map›Paper›PMID 39318991›Full record

ArticleJournal of inflammation research2024

An Experimental Animal Study: Electroacupuncture Facilitates Antiviral Immunity Against Hepatitis B Virus Through the IFN-γ/JAK/STAT Axis.

Yan Yang, Feilin Ge, Chen Luo, Cai Liao, Junyuan Deng, Yunhao Yang, Yang Chen, Xiao Guo, Zhaofang Bai, Xiaohe Xiao and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of inflammation research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yan Yang *College of Traditional Chinese Medicine, Chongqing Medical University, Chongqing, 400010, People's Republic of China.
Feilin Ge *Department of Chinese Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, People's Republic of China.
Chen LuoCollege of Traditional Chinese Medicine, Chongqing Medical University, Chongqing, 400010, People's Republic of China.
Cai LiaoCollege of Traditional Chinese Medicine, Chongqing Medical University, Chongqing, 400010, People's Republic of China.
Junyuan DengCollege of Traditional Chinese Medicine, Chongqing Medical University, Chongqing, 400010, People's Republic of China.
Yunhao YangCollege of Traditional Chinese Medicine, Chongqing Medical University, Chongqing, 400010, People's Republic of China.
Yang ChenCollege of Traditional Chinese Medicine, Chongqing Medical University, Chongqing, 400010, People's Republic of China.
Xiao GuoCollege of Traditional Chinese Medicine, Chongqing Medical University, Chongqing, 400010, People's Republic of China.
Zhaofang BaiSenior Department of Hepatology, the Fifth Medical Center of Chinese PLA General Hospital, Beijing, 100039, People's Republic of China.ORCID 0000-0002-6208-150X
Xiaohe XiaoSenior Department of Hepatology, the Fifth Medical Center of Chinese PLA General Hospital, Beijing, 100039, People's Republic of China.
Chenglin TangCollege of Traditional Chinese Medicine, Chongqing Medical University, Chongqing, 400010, People's Republic of China.ORCID 0000-0002-9628-9616

Funding

HSRD VA I01 HX000630
6 · The paper itself

Abstract

Background: Chronic hepatitis B (CHB) remains a global health challenge, necessitating innovative therapeutic strategies. Enhancing the body's immune response against the hepatitis B virus (HBV) emerges as a fundamental strategy for achieving a functional cure. While acupuncture has shown potential in immune modulation, its specific anti-HBV effects are not well understood. This study evaluates the potential of electroacupuncture (EA) in HBV infection and explores its underlying immunological mechanisms using a mouse model. Methods: HBV-infected mice were established using the high-pressure hydrodynamic method and divided into four groups: normal saline (NS), EA, sham EA (SE), and tenofovir disoproxil fumarate (TF), with n = 6 per group. During treatment, blood was collected every Sunday via the orbital sinus to monitor HBV DNA, HBsAg, and HBeAg levels. Transcriptomics and metabolomics analyses were employed to unearth clues regarding EA's anti-HBV mechanism. Validation of these mechanisms included splenic T-cell flow analysis, Western blotting, RT-qPCR, immunofluorescence, and ELISA. Results: Serum HBV DNA levels decreased by 1.10, 0.19, and 1.98 log Conclusion: EA manifests inhibitory effects on HBV, particularly in antigen suppression, with its mode of action intricately linked to the regulation of IFN-γ/JAK/STAT.

Indexed as

antiviral activityelectroacupuncturehepatitis B virusIFN-γimmune modulation

Identifiers

PMID39318991
PMCPMC11420899

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.