ArticleEClinicalMedicine2024
Associations of socioeconomic status and healthy lifestyle with incident dementia and cognitive decline: two prospective cohort studies.
Article in EClinicalMedicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- Divergent associations of estimated cardiorespiratory fitness with cognitive trajectories in Chinese and U.S. middle-aged and older adults: A descriptive cross-national comparison from CHARLS and HRS.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Observational
- Association of Changes in Intrinsic Capacity With Cognitive Decline and Dementia: A Prospective Cohort Study.Neurology · 2026Article
- Income, diet, and cognitive function: observational analyses and candidate metabolomic pathways identified by Mendelian randomization.The journal of prevention of Alzheimer's disease · 2026Observational
- The mediating role of healthy lifestyle in the association between higher socioeconomic status and an increased risk of allergic rhinitis: an analysis of NHANES.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026Article
- A longitudinal study of socioeconomic status and cognitive function in middle-aged and older adults in China: random intercept cross-lagged panel analysis.Cognitive processing · 2026Article
- Proteome-wide genetic study identified therapeutic targets for early-onset and late-onset Alzheimer's disease.International journal of surgery (London, England) · 2026Article
- Socioeconomic inequalities in healthy ageing: functional capacity and community participation in older adults across 22 countries.BMC public health · 2026Article
- Women's reproductive life patterns, intrinsic capacity, and the risk of all-cause and cause-specific dementia: a prospective cohort study.Alzheimer's research & therapy · 2026Article
- The Association Between Family Health and Proactive Health Risk Management With the Mediating Role of Health Literacy: Nationwide Cross-Sectional Study.JMIR public health and surveillance · 2026Article
- The Association Between Social Determinants of Health and Alzheimer Disease Blood Biomarkers in Midlife.medRxiv : the preprint server for health sciences · 2026Article
- Causal machine learning analysis identifies subpopulations most likely to benefit from healthy lifestyles for cognitive outcomes.General psychiatry · 2026Article
- Prevalence and risk factors of cognitive impairment among geriatric patients at Prince Sultan Military Hospital, Taif, Saudi Arabia.Journal of family medicine and primary care · 2026Article
- Socioeconomic status and intrinsic capacity trajectories among middle-aged and older adults in China: mediating role of cognitive leisure activities.The journal of nutrition, health & aging · 2026Article
- Article
- Integrative Multimodal Subtyping, Risk of Incident Mild Cognitive Impairment, and Differential Cardiometabolic Treatment Effects: A Prospective Cohort Study in the All of Us Research Program.medRxiv : the preprint server for health sciences · 2026Article
- Predicting rates of cognitive and functional decline in Alzheimer's disease and mild cognitive impairment.Communications medicine · 2026Article
- Hearing screening for healthy aging: the U.K. should take a targeted approach.The Gerontologist · 2026Article
- Disentangling Responsibility: Perspectives on Dementia Prevention From Stakeholders in Canada, Germany and Switzerland.Sociology of health & illness · 2026Article
- Associations of life course social determinants of health, social mobility with cognitive function and roles of social participation and lifestyle: a multicohort study.BMC medicine · 2025Article
- Protective Effects of Socioeconomic Status and Lifestyle on Amyloid- and White Matter Hyperintensity-Related Longitudinal Brain Atrophy and Cognitive Decline.Annals of neurology · 2025Article
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Authors and funding
10 authors.
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Abstract
Background: Little is known about the complex associations of socioeconomic status (SES) and healthy lifestyle with cognitive dysfunction. Methods: Using data from the Health and Retirement Study (HRS) [2008-2020] and the English Longitudinal Study of Ageing (ELSA) [2004-2018], SES was constructed by latent class analysis using education level, total household income and wealth. Overall healthy lifestyle was derived using information on never smoking, low to moderate alcohol consumption (drinks/day: (0, 1] for women and (0, 2] for men), top tertile of physical activity, and active social contact. Findings: A total of 12,437 and 6565 participants from the HRS and ELSA were included (40.8% and 46.0% men and mean age 69.3 years and 65.1 years, respectively). Compared with participants of high SES, those of low SES had higher risk of incident dementia (hazard ratio 3.17, 95% confidence interval 2.72-3.69 in the HRS; 1.43, 1.09-1.86 in the ELSA), and the proportions mediated by overall lifestyle were 10.4% (7.3%-14.6%) and 2.7% (0.5%-14.0%), respectively. Compared with participants of high SES and favorable lifestyle, those with low SES and unfavorable lifestyle had a higher risk of incident dementia (4.27, 3.40-5.38 in the HRS; 2.02, 1.25-3.27 in the ELSA) and accelerated rate of global cognitive decline ( Interpretation: Unhealthy lifestyle only mediated a small proportion of the socioeconomic inequality in dementia risk in both US and UK older adults. Funding: This work was supported by grants from the National Natural Science Foundation of China (82088102 and 82370819), the National Key R&D Program of China (2023YFC2506700), the Shanghai Municipal Government (22Y31900300), the Shanghai Clinical Research Center for Metabolic Diseases (19MC1910100), the Innovative Research Team of High-Level Local Universities in Shanghai, the Special Project for Clinical Research in Health Industry of Shanghai Municipal Health Commission (202340084), and Ruijin Hospital Youth Incubation Project (KY20240805). Y.X. is supported by the National Top Young Talents program.
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