Evidence map›Paper›PMID 39318715›Full record

ArticleThe Lancet regional health. Western Pacific2024

Invasive fungal disease and antifungal prophylaxis in children with acute leukaemia: a multicentre retrospective Australian cohort study.

Daniel K Yeoh, Christopher C Blyth, Julia E Clark, Joanne Abbotsford, Claudia Corrente, Sara Cook, Rishi S Kotecha, Stacie S Wang, Tim Spelman, Monica A Slavin and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Lancet regional health. Western Pacific, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Fungal Infections in Pediatric Patients With Hematologic Malignancies and Stem Cell Transplantation: Impact on the Upper and Lower Respiratory Systems.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2026
    Review
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Daniel K YeohSir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Australia.
Christopher C BlythDepartment of Infectious Diseases, Perth Children's Hospital, Perth, Australia.
Julia E ClarkInfection Management Service, Queensland Children's Hospital, Brisbane, Australia.
Joanne AbbotsfordDepartment of Infectious Diseases, Perth Children's Hospital, Perth, Australia.
Claudia CorrenteMurdoch Children's Research Institute, Melbourne, Australia.
Sara CookInfection Management Service, Queensland Children's Hospital, Brisbane, Australia.
Rishi S KotechaDepartment of Clinical Haematology, Oncology, Blood and Marrow Transplantation, Perth Children's Hospital, Perth, Australia.
Stacie S WangMurdoch Children's Research Institute, Melbourne, Australia.
Tim SpelmanNational Centre for Infections in Cancer, Peter MacCallum Cancer Centre, Melbourne, Australia.
Monica A SlavinSir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Australia.
Karin A ThurskySir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Australia.
Gabrielle M HaeuslerSir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Invasive fungal disease (IFD) is a significant complication for children receiving treatment for leukaemia, contributing to morbidity and mortality. Recent regional paediatric epidemiological IFD data are lacking. Additionally uncertainty remains regarding the optimal prophylactic approach in this context. Methods: In a multi-centre Australian cohort study of children diagnosed with Findings: A total of 434 children were included (47.2% female; median age 5.0 years, median follow-up 240 days). This cohort included 351 children with ALL (214 high-risk [HR-ALL]; 137 standard-risk [SR-ALL]), and 73 with AML. The prevalence of proven/probable IFD was 6.8% for AML, 14.0% for HR-ALL and 4.4% for SR-ALL. A mould was implicated as the causative pathogen in almost two thirds of cases. Antifungal prophylaxis was prescribed in 98.7% of chemotherapy cycles for AML, 56.7% for HR-ALL and 14.9% for SR-ALL. A mould-active agent was used in 77.4% of AML cycles and 21.2% of HR-ALL cycles. Mould-active prophylaxis was associated with a lower risk of IFD overall and increased IFD-free survival in AML. Interpretation: These data demonstrate the persistent high regional burden of IFD in children with HR-ALL, and the potential for mould-active prophylaxis to ameliorate this. Strategies to increase uptake of appropriate prophylaxis are required in this cohort. Funding: This study was supported by a Perth Children's Hospital Foundation grant (PCHF9973).

Indexed as

Acute lymphoblastic leukaemiaAcute myeloid leukaemiaAntifungal prophylaxisChildrenInvasive fungal diseaseInvasive fungal infections

Identifiers

PMID39318715
PMCPMC11417227

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.