Evidence map›Paper›PMID 39318710›Full record

ArticleOphthalmology science

Lens Thickness in Infants and Children with Cataracts.

Libby Wei, Taylor Kolosky, Sarah Byun, Alexandra S Dolgetta, Moran R Levin, Jana A Friedman, Monica M Manrique, Isabelle Dortonne, Camilo Martinez, Marlet Bazemore and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Ophthalmology science. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Libby WeiDepartment of Ophthalmology and Visual Sciences, University of Maryland School of Medicine, Baltimore, Maryland.
Taylor KoloskyDepartment of Ophthalmology and Visual Sciences, University of Maryland School of Medicine, Baltimore, Maryland.
Sarah ByunDepartment of Ophthalmology and Visual Sciences, University of Maryland School of Medicine, Baltimore, Maryland.
Alexandra S DolgettaDepartment of Ophthalmology and Visual Sciences, University of Maryland School of Medicine, Baltimore, Maryland.
Moran R LevinDepartment of Ophthalmology and Visual Sciences, University of Maryland School of Medicine, Baltimore, Maryland.
Jana A FriedmanDepartment of Ophthalmology and Visual Sciences, University of Maryland School of Medicine, Baltimore, Maryland.
Monica M ManriqueDepartment of Ophthalmology, Children's National Health System, Washington, District of Columbia.
Isabelle DortonneDepartment of Ophthalmology, Children's National Health System, Washington, District of Columbia.
Camilo MartinezDepartment of Ophthalmology, Children's National Health System, Washington, District of Columbia.
Marlet BazemoreDepartment of Ophthalmology, Children's National Health System, Washington, District of Columbia.
Mohamad S JaafarDepartment of Ophthalmology, Children's National Health System, Washington, District of Columbia.
William P MadiganDepartment of Ophthalmology, Children's National Health System, Washington, District of Columbia.
Laurence MagderDepartment of Biostatistics, Epidemiology, and Public Health, University of Maryland School of Medicine, Baltimore, Maryland.
Janet L AlexanderDepartment of Ophthalmology and Visual Sciences, University of Maryland School of Medicine, Baltimore, Maryland.

Funding

QAQC Johns Hopkins Institute for Clinical and Translational ResearchUL1TR003098 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2019 to 2023
$57.7M
Institutional Career Development CoreKL2TR003099 · NCATS · JOHNS HOPKINS UNIVERSITY · PI GEBO, KELLY A · 2019 to 2023
$7.9M
Identification of Anterior Segment Structural Biomarkers in Glaucoma Following Pediatric Cataract Using Ultrasound BiomicroscopyK23EY032525 · NEI · UNIVERSITY OF MARYLAND BALTIMORE · PI ALEXANDER, JANET LEATH · 2022 to 2024
$709k
NCATS NIH HHS KL2 TR003099NCATS NIH HHS UL1 TR003098NEI NIH HHS K23 EY032525
6 · The paper itself

Abstract

Purpose: The purpose of this study was to determine the association between lens thickness and cataract in participants aged 0 to 5 years. Design: This was a prospective, multicenter, case-control study. Participants: We enrolled 118 participants (171 eyes) aged 0 to 5 years, mean age 14.6 ± 17.0 months, range 0 to 60 months. Methods: Lens thickness was measured on 342 ultrasound biomicroscopy (UBM) images. Main Outcome Measures: Lens thickness; feasibility of lens thickness measurement from UBM images. Results: The mean lens thickness among noncataracts was 3.60 ± 0.17 mm, compared with 3.16 ± 0.61 mm among cataracts ( Conclusions: Quantitative UBM can be used to evaluate lens thickness in infants and children with congenital cataracts. The lens in congenital cataract eyes was thinner than that of controls among infants. Abnormal lens thickness was significantly associated with cataract. Future longitudinal studies will examine the association between lens thickness and postcataract surgery outcomes. Financial Disclosures: Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.

Indexed as

Congenital cataractHigh frequency ultrasoundLens developmentLens thicknessUltrasound biomicroscopy

Identifiers

PMID39318710
PMCPMC11421318

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.