Evidence map›Paper›PMID 39318183›Full record

Observational studyRespirology (Carlton, Vic.)2025

Coronary artery calcification detected on low-dose computed tomography in high-risk participants of an Australian lung cancer screening program: A prospective observational study.

Asha Bonney, Michelle Chua, Mark W McCusker, Diane Pascoe, Subodh B Joshi, Daniel Steinfort, Henry Marshall, Jeremy D Silver, Cheng Xie, Sally Yang and 11 more

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Respirology (Carlton, Vic.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Observational
  4. Observational
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Asha BonneyDepartment of Medicine, University of Melbourne, Melbourne, Victoria, Australia.ORCID 0000-0003-3647-3902
Michelle ChuaDepartment of Radiology, Royal Melbourne Hospital, Melbourne, Victoria, Australia.
Mark W McCuskerDepartment of Radiology, Royal Melbourne Hospital, Melbourne, Victoria, Australia.
Diane PascoeDepartment of Radiology, Royal Melbourne Hospital, Melbourne, Victoria, Australia.
Subodh B JoshiDepartment of Cardiology, Royal Melbourne Hospital, Melbourne, Victoria, Australia.
Daniel SteinfortDepartment of Medicine, University of Melbourne, Melbourne, Victoria, Australia.ORCID 0000-0002-8998-2949
Henry MarshallThoracic Research Centre, University of Queensland, Chermside, Queensland, Australia.ORCID 0000-0002-9626-8014
Jeremy D SilverStatistical Consulting Centre, School of Mathematics and Statistics, University of Melbourne, Melbourne, Victoria, Australia.
Cheng XieDepartment of Respiratory and Sleep Medicine, Royal Melbourne Hospital, Melbourne, Victoria, Australia.
Sally YangDepartment of Respiratory and Sleep Medicine, Royal Melbourne Hospital, Melbourne, Victoria, Australia.
Jack WatsonDepartment of Respiratory and Sleep Medicine, Royal Melbourne Hospital, Melbourne, Victoria, Australia.
Paul FogartyRespiratory Department, Epworth Eastern Hospital, Box Hill, Victoria, Australia.
Emily StoneDepartment of Thoracic Medicine and Lung Transplantation, St Vincent's Hospital, Darlinghurst, New South Wales, Australia.ORCID 0000-0001-9021-8449
Fraser BrimsDepartment of Respiratory Medicine, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia.ORCID 0000-0002-6725-7535
Annette McWilliamsDepartment of Respiratory Medicine, Fiona Stanley Hospital, Murdoch, Western Australia, Australia.ORCID 0000-0002-3799-8527
XinXin HuDepartment of Thoracic Medicine and Lung Transplantation, St Vincent's Hospital, Darlinghurst, New South Wales, Australia.
Christopher RofeDepartment of Thoracic Medicine and Lung Transplantation, St Vincent's Hospital, Darlinghurst, New South Wales, Australia.
Brad MilnerDepartment of Thoracic Medicine and Lung Transplantation, St Vincent's Hospital, Darlinghurst, New South Wales, Australia.
Stephen LamDepartment of Medicine, The University of British Columbia, Vancouver, British Columbia, Canada.
Kwun M FongThoracic Research Centre, University of Queensland, Chermside, Queensland, Australia.
Renee ManserDepartment of Medicine, University of Melbourne, Melbourne, Victoria, Australia.

Funding

Medical Research Futures Fund (MRFF) Practitioner Fellowship 1154446National Health and Medical Research Council (NHMRC) 1099154NHMRC Postgraduate Scholarship APP2005195Royal Melbourne Hospital RMH Emerging Research Leader Grant
6 · The paper itself

Abstract

BACKGROUND AND

objectivesCoronary artery calcification (CAC) is a frequent additional finding on lung cancer screening (LCS) low-dose computed tomography (LDCT). Cardiovascular disease (CVD) is a major cause of death in LCS participants. We aimed to describe prevalence of incidental CAC detected on LDCT in LCS participants without prior history of coronary artery disease (CAD), evaluate their CVD risk and describe subsequent investigation and management.

methodsProspective observational nested cohort study including all participants enrolled at a single Australian site of the International Lung Screen Trial. Baseline LDCTs were reviewed for CAC, and subsequent information collected regarding cardiovascular health. 5-year CVD risk was calculated using the AusCVD risk calculator.

results55% (226/408) of participants had CAC on LDCT and no prior history of CAD, including 23% with moderate-severe CAC. Mean age of participants with CAC was 65 years, 68% were male. 53% were currently smoking. Majority were high risk (51%) or intermediate risk (32%) of a cardiovascular event in 5 years. 21% of participants were re-stratified to a higher CVD risk group when CAC detected on LCS was incorporated. Only 10% of participants with CAC received lifestyle advice (only 3% currently smoking received smoking cessation advice). 80% of participants at high-risk did not meet guideline recommendations, with 47% of this group remaining without cholesterol lowering therapy.

conclusionLCS with LDCT offers the potential to identify and communicate CVD risk in this population. This may improve health outcomes for high-risk LCS participants and further personalize management once screening results are known.

Indexed as

Coronary Artery DiseaseEarly Detection of CancerLung NeoplasmsTomography, X-Ray ComputedVascular CalcificationAgedAustraliaFemaleHumansIncidental FindingsMaleMass ScreeningMiddle AgedPrevalenceProspective StudiesRisk Assessmentcardiovascular diseasecomputed tomographycoronary artery calcificationlung cancerscreening

Identifiers

PMID39318183
PMCPMC11688628

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.