Evidence map›Paper›PMID 39318101›Full record

ArticleCancer science2024

BBOX1-AS1 promotes gastric cardia adenocarcinoma progression via interaction with CtBP2 to facilitate the epithelial-mesenchymal transition process.

Wenxu Zou, Qing Yin, Wei Guo, Zhiming Dong, Yanli Guo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Wenxu ZouHebei Cancer Institute, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
Qing YinHebei Cancer Institute, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
Wei GuoHebei Cancer Institute, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.ORCID https://orcid.org/0000-0001-9690-161X
Zhiming DongHebei Cancer Institute, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
Yanli GuoHebei Cancer Institute, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.ORCID https://orcid.org/0009-0000-3639-1574

Funding

Clinical Medicine Talent Training Project funded by Government ZF2024112Research Innovation Team Project of Hebei Medical University Fourth Hospital 2023C12S&T Program of Hebei 22377721DS&T Program of Hebei 22377730DS&T Program of Hebei H2020206368
6 · The paper itself

Abstract

It is recognized that lncRNA BBOX1-AS1 exerts a crucial oncogenic property in several cancer types. However, the functions and underlying mechanisms of BBOX1-AS1 in the epithelial-mesenchymal transition (EMT) process of gastric cardia adenocarcinoma (GCA) have remained unclarified. The findings of this study demonstrated that GCA tissues had elevated BBOX1-AS1 expression levels, which was associated with a worse prognosis in GCA patients. BBOX1-AS1 dramatically enhanced cell proliferation, invasion, and TGF-β1-induced the EMT process in vitro. Further mechanism analysis revealed that BBOX1-AS1 could combine with CtBP2 and strengthen the interaction of CtBP2 and ZEB1. BBOX1-AS1 might regulate the E-cadherin expression through CtBP2/ZEB1 transcriptional complex-mediated transcriptional repression, further affecting the activation of the Wnt/β-catenin pathway and the EMT process. Overall, our findings demonstrate that BBOX1-AS1 might act as an lncRNA associated with EMT for facilitating GCA advancement via interaction with CtBP2 to facilitate the activation of Wnt/β-catenin pathway and the EMT process, which indicated that it might function as an exploitable treatment target for GCA patients.

Indexed as

AdenocarcinomaAlcohol OxidoreductasesCell ProliferationCo-Repressor ProteinsEpithelial-Mesenchymal TransitionGene Expression Regulation, NeoplasticRNA, Long NoncodingStomach NeoplasmsWnt Signaling PathwayZinc Finger E-box-Binding Homeobox 1CadherinsCardiaCell Line, TumorCell MovementDisease ProgressionFemaleAlcohol OxidoreductasesCadherinsCo-Repressor ProteinsCTBP2 protein, humanRNA, Long NoncodingTransforming Growth Factor beta1ZEB1 protein, humanZinc Finger E-box-Binding Homeobox 1BBOX1‐AS1CtBP2epithelial mesenchymal transitiongastric cardia adenocarcinomaWnt/β‐catenin signaling pathway

Identifiers

PMID39318101
PMCPMC11611761

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.