Evidence map›Paper›PMID 39318045›Full record

ArticleBritish journal of haematology2024

Impaired microvascular function in patients with sickle cell anemia and leg ulcers improved with healing.

Judith Catella, Etienne Turpin, Philippe Connes, Elie Nader, Romain Carin, Marie Martin, Hamdi Rezigue, Christophe Nougier, Yesim Dargaud, Audrey Josset-Lamaugarny and 10 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in British journal of haematology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04983654 (Functional and Mechanistic Characterization of Limb Ulcers in Patients With Sickle Cell Disease), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04983654 nacompletednot on this map

Functional and Mechanistic Characterization of Limb Ulcers in Patients With Sickle Cell Disease

TypeinterventionalSponsorHospices Civils de LyonRan2022 to 2023Enrolled70ConditionsUlcer, Anemia, Sickle Cell DiseaseArmspatients with limb ulcers, For patients without limb ulcers
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Judith CatellaService de Médecine Interne et Vasculaire, Hôpital Edouard Herriot, Hospices Civils de Lyon, Lyon, France.ORCID https://orcid.org/0000-0001-8028-6827
Etienne TurpinLaboratoire d'Excellence du Globule Rouge (Labex GR-Ex), Sorbonne, Paris, France.
Philippe ConnesLaboratoire d'Excellence du Globule Rouge (Labex GR-Ex), Sorbonne, Paris, France.
Elie NaderLaboratoire d'Excellence du Globule Rouge (Labex GR-Ex), Sorbonne, Paris, France.
Romain CarinLaboratoire d'Excellence du Globule Rouge (Labex GR-Ex), Sorbonne, Paris, France.
Marie MartinLaboratoire d'Excellence du Globule Rouge (Labex GR-Ex), Sorbonne, Paris, France.
Hamdi RezigueService d'hématologie-hémostase, Hospices civils de Lyon, Bron, France.ORCID https://orcid.org/0009-0003-3765-3603
Christophe NougierService d'hématologie-hémostase, Hospices civils de Lyon, Bron, France.
Yesim DargaudEA 4609-Hémostase et cancer, UFR Laennec, Université Claude Bernard, Lyon 1, France.
Audrey Josset-LamaugarnyLaboratoire de Biologie Tissulaire et Ingénierie Thérapeutique (LBTI UMR 5305), CNRS/Université Claude Bernard Lyon 1, Lyon, France.
Justine DugrainLaboratoire de Biologie Tissulaire et Ingénierie Thérapeutique (LBTI UMR 5305), CNRS/Université Claude Bernard Lyon 1, Lyon, France.
Muriel MaranoEA 4609-Hémostase et cancer, UFR Laennec, Université Claude Bernard, Lyon 1, France.
Alexandre LeuciEA 4609-Hémostase et cancer, UFR Laennec, Université Claude Bernard, Lyon 1, France.
Camille BoissonLaboratoire Interuniversitaire de Biologie de la Motricité (LIBM) EA7424, Equipe «Biologie Vasculaire et du Globule Rouge», Université Claude Bernard Lyon 1, Université de Lyon, Lyon, France.
Celine RenouxLaboratoire d'Excellence du Globule Rouge (Labex GR-Ex), Sorbonne, Paris, France.ORCID https://orcid.org/0000-0002-7263-805X
Philippe JolyLaboratoire d'Excellence du Globule Rouge (Labex GR-Ex), Sorbonne, Paris, France.ORCID https://orcid.org/0000-0002-2351-9441
Solène PoutrelService de Médecine Interne et Vasculaire, Hôpital Edouard Herriot, Hospices Civils de Lyon, Lyon, France.
Arnaud HotService de Médecine Interne et Vasculaire, Hôpital Edouard Herriot, Hospices Civils de Lyon, Lyon, France.
Nicolas GuillotLaboratoire d'Excellence du Globule Rouge (Labex GR-Ex), Sorbonne, Paris, France.
Berengère FromyLaboratoire de Biologie Tissulaire et Ingénierie Thérapeutique (LBTI UMR 5305), CNRS/Université Claude Bernard Lyon 1, Lyon, France.

Funding

Hospices Civils de Lyon
6 · The paper itself

Abstract

Leg Ulcer (LU) pathophysiology is still not well understood in sickle cell anaemia (SCA). We hypothesised that SCA patients with LU would be characterised by lower microvascular reactivity. The aim of the present study was to compare the microcirculatory function (transcutaneous oxygen pressure (TcPO

Indexed as

Anemia, Sickle CellLeg UlcerMicrocirculationWound HealingAdultFemaleHumansLaser-Doppler FlowmetryMaleMicrovesselsMiddle AgedSkinVasodilationYoung Adultendothelial cellleg ulcersmicrocirculationsickle cell diseasetranscutaneous oxygen pressure

Identifiers

PMID39318045
PMCPMC11637740

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.