Evidence map›Paper›PMID 39317889›Full record

ReviewMolecular neurobiology2025

Gut Microbiota Mediates Neuroinflammation in Alzheimer's Disease: Unraveling Key Factors and Mechanistic Insights.

Liang Junyi, Wang Yueyang, Liu Bin, Dong Xiaohong, Cai Wenhui, Zhang Ning, Zhang Hong

Abstract readReview
PubMed Publisher
In one paragraph

Review in Molecular neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Review
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  13. Minocycline AmelioratesBrain sciences · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Liang JunyiHeilongjiang University of Traditional Chinese Medicine, Harbin, 150040, Heilongjiang Province, China.
Wang YueyangHeilongjiang University of Traditional Chinese Medicine, Harbin, 150040, Heilongjiang Province, China.
Liu BinHeilongjiang University of Traditional Chinese Medicine, Harbin, 150040, Heilongjiang Province, China. liubin169@163.com.
Dong XiaohongJiamusi College, Heilongjiang University of Traditional Chinese Medicine, Jiamusi, Heilongjiang Province, China.
Cai WenhuiHeilongjiang University of Traditional Chinese Medicine, Harbin, 150040, Heilongjiang Province, China.
Zhang NingHeilongjiang University of Traditional Chinese Medicine, Harbin, 150040, Heilongjiang Province, China.
Zhang HongHeilongjiang Jiamusi Central Hospital, Jiamusi, Heilongjiang Province, China.

Funding

Innovative Research Project for Postgraduate Students of Heilongjiang University of Traditional Chinese Medicine No. 2024yjscx013Natural Science Foundation of Heilongjiang Province of China No.LH2023H073
6 · The paper itself

Abstract

The gut microbiota, the complex community of microorganisms that inhabit the gastrointestinal tract, has emerged as a key player in the pathogenesis of neurodegenerative disorders, including Alzheimer's disease (AD). AD is characterized by progressive cognitive decline and neuronal loss, associated with the accumulation of amyloid-β plaques, neurofibrillary tangles, and neuroinflammation in the brain. Increasing evidence suggests that alterations in the composition and function of the gut microbiota, known as dysbiosis, may contribute to the development and progression of AD by modulating neuroinflammation, a chronic and maladaptive immune response in the central nervous system. This review aims to comprehensively analyze the current role of the gut microbiota in regulating neuroinflammation and glial cell function in AD. Its objective is to deepen our understanding of the pathogenesis of AD and to discuss the potential advantages and challenges of using gut microbiota modulation as a novel approach for the diagnosis, treatment, and prevention of AD.

Indexed as

Alzheimer DiseaseGastrointestinal MicrobiomeInflammationNeuroinflammatory DiseasesAnimalsBrainDysbiosisHumansAlzheimer’s diseaseDysbiosisGut microbiotaMicrobiota-gut-brain axisNeuroinflammation

Identifiers

PMID39317889

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.