Evidence map›Paper›PMID 39317838›Full record

ReviewNature reviews. Cardiology2025

Soil and water pollution and cardiovascular disease.

Thomas Münzel, Omar Hahad, Jos Lelieveld, Michael Aschner, Mark J Nieuwenhuijsen, Philip J Landrigan, Andreas Daiber

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Cardiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
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  6. Review
  7. Article
  8. Article
  9. On-chip trace detection of CdCommunications engineering · 2026
    Article
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  11. Article
  12. Review
  13. Review
  14. A perspective on the future of heart failure research.Journal of molecular and cellular cardiology plus · 2026
    Article
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  16. Review
  17. Review
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  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Thomas MünzelUniversity Medical Center Mainz, Department of Cardiology, Johannes Gutenberg University Mainz, Mainz, Germany. tmuenzel@uni-mainz.de.ORCID 0000-0001-5503-4150
Omar HahadUniversity Medical Center Mainz, Department of Cardiology, Johannes Gutenberg University Mainz, Mainz, Germany.ORCID 0000-0001-7823-7671
Jos LelieveldAtmospheric Chemistry Department, Max Planck Institute for Chemistry, Mainz, Germany.
Michael AschnerDepartment of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY, USA.ORCID 0000-0002-2619-1656
Mark J NieuwenhuijsenCenter for Research in Environmental Epidemiology (CREAL), Barcelona, Spain.
Philip J LandriganGlobal Observatory on Planetary Health, Boston College, Boston, MA, USA.
Andreas DaiberUniversity Medical Center Mainz, Department of Cardiology, Johannes Gutenberg University Mainz, Mainz, Germany.ORCID 0000-0002-2769-0094

Funding

Mechanisms of Manganese NeurotoxicityR01ES010563 · NIEHS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Michael Aschner, Aaron B Bowman · 2001 to 2026
$11.9M
Mechanisms of Methylmercury Induced Neuron ToxicityR01ES007331 · NIEHS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Michael Aschner, Aaron B Bowman · 1996 to 2026
$10.6M
NIEHS NIH HHS R01 ES007331NIEHS NIH HHS R01 ES010563
6 · The paper itself

Abstract

Healthy, uncontaminated soils and clean water support all life on Earth and are essential for human health. Chemical pollution of soil, water, air and food is a major environmental threat, leading to an estimated 9 million premature deaths worldwide. The Global Burden of Disease study estimated that pollution was responsible for 5.5 million deaths related to cardiovascular disease (CVD) in 2019. Robust evidence has linked multiple pollutants, including heavy metals, pesticides, dioxins and toxic synthetic chemicals, with increased risk of CVD, and some reports suggest an association between microplastic and nanoplastic particles and CVD. Pollutants in soil diminish its capacity to produce food, leading to crop impurities, malnutrition and disease, and they can seep into rivers, worsening water pollution. Deforestation, wildfires and climate change exacerbate pollution by triggering soil erosion and releasing sequestered pollutants into the air and water. Despite their varied chemical makeup, pollutants induce CVD through common pathophysiological mechanisms involving oxidative stress and inflammation. In this Review, we provide an overview of the relationship between soil and water pollution and human health and pathology, and discuss the prevalence of soil and water pollutants and how they contribute to adverse health effects, focusing on CVD.

Indexed as

Cardiovascular DiseasesEnvironmental ExposureSoil PollutantsWater PollutionHumansRisk AssessmentRisk FactorsSoil Pollutants

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.