Evidence map›Paper›PMID 39317833›Full record

Trial reportCanadian journal of anaesthesia = Journal canadien d'anesthesie2024

Characterizing usual-care physical rehabilitation in Canadian intensive care unit patients: a secondary analysis of the Canadian multicentre Critical Care Cycling to Improve Lower Extremity Strength pilot randomized controlled trial.

Heather K O'Grady, Ian Ball, Sue Berney, Karen E A Burns, Deborah J Cook, Alison Fox-Robichaud, Margaret S Herridge, Timothy Karachi, Sunita Mathur, Julie C Reid and 6 more

Erratum issued Registry-linked trialAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT02377830 (CYCLE Pilot), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02377830 phase2completednot on this map

CYCLE Pilot: A Pilot Randomized Study of Early Cycle Ergometry Versus Routine Physiotherapy in Mechanically Ventilated Patients

TypeinterventionalSponsorMcMaster UniversityRan2015 to 2018Enrolled113ConditionsIntensive Care Unit Acquired Weakness, Critical Care, Mechanical Ventilation, Respiratory FailureArmsIn-bed cycle ergometer (Restorative Therapies RT300 Supine), Routine physiotherapy
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Heather K O'GradySchool of Rehabilitation Science, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada.ORCID 0000-0002-1771-1824
Ian BallDepartment of Medicine, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada.
Sue BerneyPhysiotherapy Clinic, Austin Health, Heidelberg, VIC, Australia.
Karen E A BurnsLi Sha King Knowledge Institute, St. Michael's Hospital, Unity Health Toronto, Toronto, ON, Canada.
Deborah J CookDepartment of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada.
Alison Fox-RobichaudDepartment of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada.
Margaret S HerridgeToronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada.
Timothy KarachiToronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada.
Sunita MathurSchool of Rehabilitation Therapy, Faculty of Health Sciences, Queen's University, Kingston, ON, Canada.
Julie C ReidDepartment of Health Research Methods, Evidence, and Impact (HEI), Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada.
Bram RochwergDepartment of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada.
Thomas RollinsonPhysiotherapy Clinic, Austin Health, Heidelberg, VIC, Australia.
Jill C RudkowskiDepartment of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada.
Jackie BoschSchool of Rehabilitation Science, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada.
Lyn S TurkstraSchool of Rehabilitation Science, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada.
Michelle E KhoSchool of Rehabilitation Science, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada. khome@mcmaster.ca.

Funding

Non-US Government Research Support
6 · The paper itself

Abstract

purposePhysical rehabilitation (PR) in the intensive care unit (ICU) may improve outcomes for survivors but clinical trial results have been discordant. We hypothesized that discordant results may reflect treatment heterogeneity received by "usual care" comparator groups in PR studies. Usual-care PR is typically underspecified, which is a barrier to comparing results across treatment studies. The primary objective of the present study was to describe the usual-care PR received by critically ill patients enrolled in the Canadian multicentre Critical Care Cycling to Improve Lower Extremity Strength (CYCLE) pilot randomized controlled trial (RCT) of PR. Other objectives were to help contextualize current research and provide data for international comparison.

methodsIn this secondary analysis of the CYCLE pilot RCT, patients were randomized to in-bed cycling and usual-care PR or usual-care PR alone. Physiotherapists documented usual-care PR including therapy received, type of activity, duration, adverse events and consequences, reasons for no PR, and concurrent relevant medical interventions. We characterized usual care using descriptive statistics at the cohort and patient levels.

resultsAcross seven Canadian centres, 30 patients were randomized to usual-care PR. The median [interquartile range (IQR)] ICU stay was 10 [9-24] days and patients received PR on a median [IQR] of 5 [3-9] days for 23 [17-30] min per day. Eighteen patients (60%) stood, marched, or walked during usual care. Transient adverse events occurred in three patients on 1.5% (3/198) of days and none prompted session termination.

conclusionsIn the usual-care arm of the CYCLE pilot RCT, PR was delivered on half of ICU days and over half of patients stood, marched, or walked. Adverse events during usual-care PR were uncommon. STUDY REGISTRATION: ClinicalTrials.gov ( NCT02377830 ); first posted 4 March 2015.

Indexed as

Critical CareCritical IllnessIntensive Care UnitsLower ExtremityMuscle StrengthAgedBicyclingCanadaFemaleHumansLength of StayMaleMiddle AgedPhysical Therapy ModalitiesPilot Projectscritical illnessrehabilitationusual care

Identifiers

PMID39317833

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.