Evidence map›Paper›PMID 39317829›Full record

ArticleJournal of molecular histology2024

Halofuginone ameliorates the susceptibility to atrial fibrillation by activating the PI3K/Akt signaling pathway.

Feng Xu, Xiaolong Zhao, Jing Zhang, Chunjian Shen

Abstract read
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Article in Journal of molecular histology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Feng Xu *Dalian Medical University, Dalian, 116044, China.
Xiaolong Zhao *Dalian Medical University, Dalian, 116044, China.
Jing Zhang *Medical Department, The Second Hospital of Dalian Medical University, Dalian, 116022, China.
Chunjian ShenDepartment of Cardiothoracic Surgery, The Fourth People's Hospital of Shenyang, No. 20 Huanghe South Street, Shenyang, Liaoning Province, 110000, China. shenchunjian1976@hotmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Atrial fibrillation (AF) is the most common cardiac arrhythmia in clinical practice. Halofuginone (HF) exerts beneficial effects on organ fibrosis, periodontitis, and cancer. However, the effect of HF against AF remains unknown. During the induction of AF, the rats were intragastrically administered HF (5 mg/kg and 10 mg/kg) daily for 7 consecutive days. Cardiac function was evaluated through echocardiographic analysis. The presence of pathological changes and interstitial fibrosis in the left atrial tissues were investigated. Intracellular Ca

Indexed as

Atrial FibrillationPhosphatidylinositol 3-KinasesPiperidinesProto-Oncogene Proteins c-aktQuinazolinonesSignal TransductionAnimalsCalciumDisease Models, AnimalDisease SusceptibilityFibrosisHeart AtriaMaleMitochondriaRatsRats, Sprague-DawleyCalciumhalofuginonePhosphatidylinositol 3-KinasesPiperidinesProto-Oncogene Proteins c-aktQuinazolinonesAtrial fibrillationCalcium ion homeostasisFibrosisHalofuginonePI3K/Akt signaling

Identifiers

PMID39317829

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.