ArticleNature neuroscience2024
A potential target for noninvasive neuromodulation of PTSD symptoms derived from focal brain lesions in veterans.
Article in Nature neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07245641 (Targeted Accelerated TMS for Post-Traumatic Stress Disorder), which is not on this map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Targeted Accelerated TMS for Post-Traumatic Stress Disorder
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Potential Targets for Scalp Acupuncture and Brain Stimulation in Mental Disorders: Evidence From Large-Scale Meta-Analyses.Alpha psychiatry · 2026Pooled it
- Personalized fMRI-Guided TMS Targeting the Threat Neurocircuitry in PTSD: A Randomized Clinical Trial.The American journal of psychiatry · 2026Trial
- Cumulative trauma, neural circuits, and burnout: an integrative model of healthcare worker post-traumatic stress syndromes.European journal of psychotraumatology · 2026Review
- Prospective Development of a Whole-Brain Connectivity and Electric Field-Guided Transcranial Magnetic Stimulation Atlas for Posttraumatic Stress Disorder Symptoms.Biological psychiatry global open science · 2026Article
- Circuit-informed modulation of traumatic memory in PTSD: integrating extinction, suppression, and reconsolidation.Molecular psychiatry · 2026Review
- Investigating the methodological foundation of lesion network mapping.Nature neuroscience · 2026Article
- Predictive value of subgenual cingulate normative connectivity to TMS treatment site for antidepressant response in routine clinical practice: a prospective, multisite cohort study.Molecular psychiatry · 2026Observational
- Body-based therapies and transcranial magnetic stimulation for posttraumatic stress disorder: a proposed integrative approach.Frontiers in psychiatry · 2026Review
- A Retrospective Chart Review of PTSD Symptoms in Military Servicemembers Participating in an Individually Guided Neuromodulation (Alpha-rTMS) Wellness Program.Neuropsychiatric disease and treatment · 2026Article
- Innovating transcranial magnetic stimulation treatment for post-traumatic stress disorder: Zapping away the bad memory.Fundamental research · 2025Review
- Effects of focal brain damage on political behaviour across different political ideologies.Brain : a journal of neurology · 2025Article
- Advancing TMS for PTSD - From networks to individuals.Transcranial magnetic stimulation (2024) · 2025Article
- A Customized Neural Transcranial Magnetic Stimulation Target for Functional Disability Among Veterans With Co-Occurring Alcohol Use Disorder and Mild Traumatic Brain Injury: Protocol for a Pilot Randomized Controlled Trial.JMIR research protocols · 2025Article
- Progress in spatiotemporal regulation of fear memory: neural circuit mechanisms and implications for PTSD.General psychiatry · 2025Review
- Individually guided neuromodulation in special operator veterans with symptoms of PTSD and traumatic brain injury: preliminary data from a chart review.Frontiers in neurology · 2025Article
- Article
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Authors and funding
11 authors.
Funding
Abstract
Neuromodulation trials for the treatment of posttraumatic stress disorder (PTSD) have yielded mixed results, and the optimal neuroanatomical target remains unclear. Here we analyzed three datasets to study brain circuitry causally linked to PTSD in military veterans. In veterans with penetrating traumatic brain injury, lesion locations that reduced probability of PTSD were preferentially connected to a circuit including the medial prefrontal cortex, amygdala and anterolateral temporal lobe. In veterans without lesions, PTSD was specifically associated with increased connectivity within this circuit. Reduced functional connectivity within this circuit after transcranial magnetic stimulation correlated with symptom reduction, even though the circuit was not directly targeted. This lesion-based 'PTSD circuit' may serve as a target for clinical trials of neuromodulation in veterans with PTSD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.