Evidence map›Paper›PMID 39317676›Full record

ArticlePhysiological reports2024

Role of L-type Ca

Francesca Schinzari, Alessandro De Stefano, Giuseppe Sica, Marco Mettimano, Carmine Cardillo, Manfredi Tesauro

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Physiological reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Role of L-type CaPhysiological reports · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Francesca SchinzariDepartment of Aging, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.
Alessandro De StefanoDepartment of Systems Medicine, Tor Vergata University, Rome, Italy.
Giuseppe SicaDepartment of Experimental Medicine, Tor Vergata University, Rome, Italy.
Marco MettimanoDepartment of Cardiovascular Sciences, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.
Carmine CardilloDepartment of Translational Medicine and Surgery, Catholic University, Rome, Italy.ORCID 0000-0001-5182-3005
Manfredi TesauroDepartment of Systems Medicine, Tor Vergata University, Rome, Italy.

Funding

Università Cattolica del Sacro Cuore (UCSC)Università degli Studi di Roma Tor Vergata (University of Rome Tor Vergata)
6 · The paper itself

Abstract

Inadequate blood supply to the expanding adipose tissue (AT) is involved in the unhealthy AT remodeling and cardiometabolic consequences of obesity. Because of the pathophysiological role of upregulated mineralocorticoid receptor (MR) signaling in the complications of obesity, this study tested the vasoactive properties of finerenone, a nonsteroidal MR antagonist, in arteries of human AT. Arteries isolated from the visceral AT of obese subjects were studied in a wire myograph. Finerenone resulted in a concentration-dependent relaxation of arteries precontracted with either the thromboxane-A2 analog U46619, ET-1, or high-K

Indexed as

Calcium Channels, L-TypeIntra-Abdominal FatMineralocorticoid Receptor AntagonistsNaphthyridinesVasodilationAdultArteriesCalcium Channel BlockersFemaleHumansMaleMiddle AgedObesityCalcium Channel BlockersCalcium Channels, L-TypefinerenoneMineralocorticoid Receptor AntagonistsNaphthyridinesadipose tissuecalcium channelsfinerenonemineralocorticoid receptorobesity

Identifiers

PMID39317676
PMCPMC11421947

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.