ArticleAngewandte Chemie (International ed. in English)2024
An Automated Electrochemical Flow Platform to Accelerate Library Synthesis and Reaction Optimization.
Article in Angewandte Chemie (International ed. in English), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed.
- An Automated Electrochemistry Platform for Accelerating the Characterization of Enzymatic Electrochemistry.ACS electrochemistry · 2026Article
- Automated air plasma-assisted functionalization of graphite electrodes for enhanced electrochemical sensing of uric acid.Mikrochimica acta · 2026Article
- Materials Acceleration Platform for Electrochemistry: a Platform for Autonomous Electrochemistry.Npj Materials degradation · 2026Article
- Homogeneous catalysis in continuous flow integrating photocatalysis, electrocatalysis, and automation technologies.Communications chemistry · 2025Review
- Real-time inline-IR-analysis via linear-combination strategy and machineś learning for automated reaction optimization.Communications chemistry · 2025Article
- Accelerated Porosity Screening Using a Multichannel Colorimetric Array.Angewandte Chemie (International ed. in English) · 2025Article
- Advancing Organic Chemistry Using High-Throughput Experimentation.Angewandte Chemie (International ed. in English) · 2025Review
- Article
- An Automated Electrochemical Flow Platform to Accelerate Library Synthesis and Reaction Optimization.Angewandte Chemie (International ed. in English) · 2024Article
- The Future of Electro-organic Synthesis in Drug Discovery and Early Development.ACS organic & inorganic Au · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Automated batch and flow setups are well-established for high throughput experimentation in both thermal chemistry and photochemistry. However, the development of automated electrochemical platforms is hindered by cell miniaturization challenges in batch and difficulties in designing effective single-pass flow systems. In order to address these issues, we have designed and implemented a new, slug-based automated electrochemical flow platform. This platform was successfully demonstrated for electrochemical C-N cross-couplings of E3 ligase binders with diverse amines (44 examples), which were subsequently transferred to a continuous-flow mode for confirmation and isolation, showing its applicability for medicinal chemistry purposes. To further validate the versatility of the platform, Design of Experiments (DoE) optimization was performed for an unsuccessful library target. This optimization process, fully automated by the platform, resulted in a remarkable 6-fold increase in reaction yield.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.