Evidence map›Paper›PMID 39317654›Full record

ArticleBMJ paediatrics open2024

Seroprotection against tetanus in HIV-exposed and HIV-unexposed infants in Malawi in 2019-2020.

Silvia Baroncelli, Clementina Maria Galluzzo, Stefano Orlando, Richard Luhanga, Robert Mphwere, Thom Kavalo, Roberta Amici, Marco Floridia, Mauro Andreotti, Fausto Ciccacci and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ paediatrics open, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Silvia BaroncelliNational Center for Global Health, Istituto Superiore di Sanita, Rome, Italy silvia.baroncelli@iss.it.ORCID http://orcid.org/0000-0002-2050-9037
Clementina Maria GalluzzoNational Center for Global Health, Istituto Superiore di Sanita, Rome, Italy.ORCID http://orcid.org/0000-0003-1392-6569
Stefano OrlandoUniversity of Rome Tor Vergata Department of Biomedicine and Prevention, Rome, Lazio, Italy.
Richard LuhangaDREAM Program, Community of S. Egidio, Blantyre, Malawi.
Robert MphwereDREAM Program, Community of S. Egidio, Blantyre, Malawi.
Thom KavaloDREAM Program, Community of S. Egidio, Blantyre, Malawi.
Roberta AmiciNational Center for Global Health, Istituto Superiore di Sanita, Rome, Italy.ORCID http://orcid.org/0000-0002-0852-9203
Marco FloridiaNational Center for Global Health, Istituto Superiore di Sanita, Rome, Italy.ORCID http://orcid.org/0000-0003-3971-0141
Mauro AndreottiNational Center for Global Health, Istituto Superiore di Sanita, Rome, Italy.ORCID http://orcid.org/0000-0001-5168-8624
Fausto CiccacciUniCamillus, Rome, Italy.
Maria Cristina MarazziLUMSA, Roma, Italy.
Marina GiulianoNational Center for Global Health, Istituto Superiore di Sanita, Rome, Italy.ORCID http://orcid.org/0000-0003-2789-7797

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In Malawi, tetanus toxoid vaccination (TTV) is recommended in pregnancy, but few studies have assessed the prevalence of infant seroprotection against tetanus. Anti-TT levels from 84 6-week-old infants, born in 2019-2020 to mothers living with HIV (HEU: HIV-exposed-uninfected) infants and to HIV-negative women (HUU: HIV-unexposed-uninfected) infants were determined by ELISA assay. Although 94% of the infants (HEU=94.8%, HUU=92.3%) showed protective levels (>0.1 IU/mL), the mean titers observed (0.51 IU/mL) suggest an incomplete compliance with TT vaccination. The only factor positively correlated to anti-TT IgG levels was the duration of maternal antiretroviral therapy in HEU.

Indexed as

HIV InfectionsTetanusTetanus ToxoidAdultAntibodies, BacterialEnzyme-Linked Immunosorbent AssayFemaleHumansInfantMalawiMalePregnancyPregnancy Complications, InfectiousVaccinationAntibodies, BacterialTetanus ToxoidHealth PolicyHIVInfantLow and Middle Income Countries

Identifiers

PMID39317654
PMCPMC11423743

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.