Evidence map›Paper›PMID 39317560›Full record

ArticleDental materials : official publication of the Academy of Dental Materials2024

Polymer vesicles for the delivery of inhibitors of cariogenic biofilm.

Parmanand Ahirwar, Veronika Kozlovskaya, Piyasuda Pukkanasut, Pavel Nikishau, Sarah Nealy, Gregory Harber, Suzanne M Michalek, Linto Antony, Hui Wu, Eugenia Kharlampieva and 1 more

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Article in Dental materials : official publication of the Academy of Dental Materials, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Parmanand AhirwarDepartment of Chemistry, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Veronika KozlovskayaDepartment of Chemistry, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Piyasuda PukkanasutDepartment of Chemistry, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Pavel NikishauDepartment of Chemistry, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Sarah NealyDepartment of Chemistry, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Gregory HarberDepartment of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Suzanne M MichalekDepartment of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Linto AntonyDepartment of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Hui WuDepartment of Integrative Biomedical and Diagnostic Sciences, Oregon Health and Science University, Portland, OR 97239, USA.
Eugenia KharlampievaDepartment of Chemistry, University of Alabama at Birmingham, Birmingham, AL 35294, USA; Center of Nanoscale Materials and Biointegration, University of Alabama at Birmingham, Birmingham, AL 35294, USA. Electronic address: ekharlam@uab.edu.
Sadanandan E VeluDepartment of Chemistry, University of Alabama at Birmingham, Birmingham, AL 35294, USA; Microbiome Center, Center, University of Alabama at Birmingham, Birmingham, AL 35294, USA; Global Center for Craniofacial Oral and Dental Disorders, University of Alabama at Birmingham, Birmingham, AL 35294, USA. Electronic address: svelu@uab.edu.

Funding

SMALL MOLECULE INHIBITORS OF CARIOGENIC BIOFILMSR01DE022350 · NIDCR · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Christian Corey Melander, Hui Wu · 2012 to 2026
$4.3M
Hydrogel encapsulated biofilm inhibitors for dental caries prevention and treatmentR21DE028349 · NIDCR · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI VELU, SADANANDAN E. · 2019 to 2020
$396k
S. mutans GTF - a novel target for dental caries preventionR03DE025058 · NIDCR · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI VELU, SADANANDAN E. · 2015 to 2016
$221k
NIDCR NIH HHS R01 DE022350NIDCR NIH HHS R03 DE025058NIDCR NIH HHS R21 DE028349
6 · The paper itself

Abstract

objectivesThe goal of this study is to develop a novel drug delivery platform for the pH-responsive delivery of biofilm inhibitors as a potential avenue to prevent and treat dental caries.

methodsBiofilm and growth inhibition assays were performed in polystyrene microtiter 96-well plates. Docking analysis was performed using the reported GtfB + HA5 co-crystal structure (PDB code: 8fg8) in SeeSAR 13.0.1 software. Polymersome vesicles were assembled from poly(N-vinylpyrrolidone)

resultsBiofilm inhibitors for HA5 and HA6 have shown species-specific selectivity towards S. mutans and the ability to preserve the oral microbiome in a S. mutans induced dental caries model. The inhibitors were encapsulated into pH-responsive block copolymer vesicles to generate polymersome-encapsulated biofilm inhibitors, and their biofilm and growth inhibitory activities against S. mutans and representative strains of oral commensal streptococci have been assessed. A 4-week treatment of S. mutans UA159 infected gnotobiotic rats with 100 µM of polymersome-encapsulated biofilm inhibitor, PEHA5 showed significant reductions in buccal, sulcal, and proximal caries scores compared to an untreated control group. SIGNIFICANCE: Taken together, our data suggests that the biofilm-selective therapy using the polymersome-encapsulated biofilm inhibitors is a viable approach for the prevention and treatment of dental caries while preserving the oral microbiome.

Indexed as

BiofilmsDental CariesPolymersStreptococcus mutansAnimalsAnti-Bacterial AgentsDisease Models, AnimalDrug Delivery SystemsHydrogen-Ion ConcentrationRatsAnti-Bacterial AgentsPolymersBiofilmDental cariesGlucosyl transferasePH-responsivePolymersomeStreptococcus mutans

Identifiers

PMID39317560
PMCPMC11580801

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.