Evidence map›Paper›PMID 39317195›Full record

ArticleCurrent biology : CB2024

A disease-associated PPP2R3C-MAP3K1 phospho-regulatory module controls centrosome function.

Anil Kumar Ganga, Lauren K Sweeney, Armando Rubio Ramos, Caitlin M Wrinn, Cassandra S Bishop, Virginie Hamel, Paul Guichard, David K Breslow

Abstract read
In one paragraph

Article in Current biology : CB, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Anil Kumar GangaDepartment of Molecular, Cellular and Developmental Biology, Yale University, 260 Whitney Avenue, New Haven, CT 06511, USA.
Lauren K SweeneyDepartment of Molecular, Cellular and Developmental Biology, Yale University, 260 Whitney Avenue, New Haven, CT 06511, USA.
Armando Rubio RamosDepartment of Molecular and Cellular Biology, Faculty of Sciences, University of Geneva, 30 Quai Ernest Ansermet, 1211 Geneva, Switzerland.
Caitlin M WrinnDepartment of Molecular, Cellular and Developmental Biology, Yale University, 260 Whitney Avenue, New Haven, CT 06511, USA.
Cassandra S BishopDepartment of Genetics, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA.
Virginie HamelDepartment of Molecular and Cellular Biology, Faculty of Sciences, University of Geneva, 30 Quai Ernest Ansermet, 1211 Geneva, Switzerland.
Paul GuichardDepartment of Molecular and Cellular Biology, Faculty of Sciences, University of Geneva, 30 Quai Ernest Ansermet, 1211 Geneva, Switzerland.
David K BreslowDepartment of Molecular, Cellular and Developmental Biology, Yale University, 260 Whitney Avenue, New Haven, CT 06511, USA. Electronic address: david.breslow@yale.edu.

Funding

Mechanisms of Primary Cilium Assembly and DisassemblyR35GM137956 · NIGMS · YALE UNIVERSITY · PI David King Breslow · 2020 to 2026
$3.1M
High Resolution Tandem Mass Spectrometer to Meet Growing Demand for Proteomics at YaleS10OD023651 · OD · YALE UNIVERSITY · PI LAM, TUKIET T · 2018 to 2018
$572k
6500 QTrap Mass Spectrometer for Yale UniversityS10OD018034 · OD · YALE UNIVERSITY · PI MANE, SHRIKANT M · 2014 to 2014
$514k
NIGMS NIH HHS R35 GM137956NIH HHS S10 OD018034NIH HHS S10 OD023651
6 · The paper itself

Abstract

Centrosomes have critical roles in microtubule organization, ciliogenesis, and cell signaling.

Indexed as

CentrosomeProtein Phosphatase 2AnimalsCell LineCentriolesHumansMAP Kinase Kinase Kinase 1PhosphorylationMAP3K1 protein, humanMAP Kinase Kinase Kinase 1PPP2R3C protein, humanProtein Phosphatase 2centriolecentrosomeciliaDepMapfunctional genomicsgonadal dysgenesiskinaseneuroblastomaphosphatasePP2A

Identifiers

PMID39317195
PMCPMC11496028

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.