Evidence map›Paper›PMID 39316682›Full record

ArticleAmerican journal of physiology. Lung cellular and molecular physiology2024

Madeline Stone, Chung-Sik Choi, Nandita Dey, Grace Swain, Troy Stevens, Sarah L Sayner

Abstract read
In one paragraph

Article in American journal of physiology. Lung cellular and molecular physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Madeline StoneDepartment of Physiology and Cell Biology, University South Alabama, Mobile, Alabama, United States.
Chung-Sik ChoiDepartment of Physiology and Cell Biology, University South Alabama, Mobile, Alabama, United States.ORCID 0000-0002-8426-4681
Nandita DeyDepartment of Physiology and Cell Biology, University South Alabama, Mobile, Alabama, United States.
Grace SwainDepartment of Physiology and Cell Biology, University South Alabama, Mobile, Alabama, United States.
Troy StevensDepartment of Physiology and Cell Biology, University South Alabama, Mobile, Alabama, United States.ORCID 0000-0001-9689-929X
Sarah L SaynerDepartment of Physiology and Cell Biology, University South Alabama, Mobile, Alabama, United States.ORCID 0000-0002-4587-6634

Funding

T-type Calcium Channels and von Willebrand Factor ReleaseP01HL066299 · NHLBI · UNIVERSITY OF SOUTH ALABAMA · PI LEAVESLEY, SILAS JOSIAH · 2001 to 2022
$34.6M
Soluble adenylyl cyclases in lung endothelial tauopathyR01HL167997 · NHLBI · UNIVERSITY OF SOUTH ALABAMA · PI Troy Stevens · 2023 to 2026
$1.9M
Lung Endothelial Aß in infectious proteinopathyR01HL148069 · NHLBI · UNIVERSITY OF SOUTH ALABAMA · PI STEVENS, TROY · 2020 to 2023
$1.5M
Bicarbonate regulation of the pulmonary endothelial barrierR01HL121513 · NHLBI · UNIVERSITY OF SOUTH ALABAMA · PI SAYNER, SARAH LOUISE · 2015 to 2019
$1.5M
HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) HL121513HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) HL148069HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) HL167997HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) HL66299NHLBI NIH HHS P01 HL066299NHLBI NIH HHS R01 HL121513NHLBI NIH HHS R01 HL148069NHLBI NIH HHS R01 HL167997
6 · The paper itself

Abstract

Type three secretion system (TTSS)-competent Pseudomonas aeruginosa expressing soluble promiscuous cyclase, exoenzyme Y (ExoY), generates cyclic nucleotides in pulmonary microvascular endothelial cells (PMVECs). Within cells, cyclic nucleotide signals are highly compartmentalized, but these second messengers are also released into the extracellular space. Although agonist stimulation of endogenous adenylyl cyclase (AC) or the presence of ExoY increases cyclic nucleotides, the proportion of the signal that is in the intracellular versus extracellular compartments is unresolved. Furthermore, it is unclear whether

Indexed as

Bacterial ProteinsCyclic AMPCyclic GMPEndothelial CellsLungPseudomonas aeruginosaPseudomonas InfectionsAdenylyl CyclasesAdrenergic beta-AgonistsAnimalsCells, CulturedExtracellular SpaceGlucosyltransferasesMicrovesselsPhosphorus-Oxygen LyasesRatsAdenylyl CyclasesAdrenergic beta-AgonistsBacterial ProteinsCyclic AMPCyclic GMPExoY protein, bacteriaGlucosyltransferasesPhosphorus-Oxygen Lyasesbeta-adrenergic responsecompartmentalizationcyclic nucleotidesPseudomonas aeruginosa ExoYpulmonary endothelium

Identifiers

PMID39316682
PMCPMC11560077

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.