Evidence map›Paper›PMID 39316676›Full record

ArticleAmerican journal of physiology. Lung cellular and molecular physiology2024

MAP2K1 dampens cigarette smoke-induced inflammation via suppression of type I interferon pathway activation.

Ke-Qin Gong, Jourdan E Brune, Xiaoyun Guo, Anne M Manicone

Abstract read
In one paragraph

Article in American journal of physiology. Lung cellular and molecular physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ke-Qin GongCenter for Lung Biology, University of Washington, Seattle, Washington, United States.ORCID 0000-0002-3290-849X
Jourdan E BruneCenter for Lung Biology, University of Washington, Seattle, Washington, United States.ORCID 0000-0001-8284-9881
Xiaoyun GuoCenter for Lung Biology, University of Washington, Seattle, Washington, United States.
Anne M ManiconeCenter for Lung Biology, University of Washington, Seattle, Washington, United States.ORCID 0000-0002-3508-4422

Funding

Vector and Transgenic Mouse CoreP30DK017047 · NIDDK · UNIVERSITY OF WASHINGTON · PI Sakeneh Zraika · 1986 to 2026
$41.4M
RESPIRATORY RESEARCH TRAINING PROGRAMT32HL007287 · NHLBI · UNIVERSITY OF WASHINGTON · PI Kristina Anne Crothers, David J. Horne · 1985 to 2026
$16.7M
MAP2K1 AND MAP2K2 IN ACUTE LUNG INJURY AND RESOLUTIONR01HL167273 · NHLBI · UNIVERSITY OF WASHINGTON · PI Anne M. Manicone · 2023 to 2026
$2.8M
Macrophage Signaling Pathways in Acute Lung Injury and ResolutionR01HL144656 · NHLBI · UNIVERSITY OF WASHINGTON · PI MANICONE, ANNE M. · 2019 to 2022
$2.4M
HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL144656HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL16727NHLBI NIH HHS R01 HL144656NHLBI NIH HHS R01 HL167273NHLBI NIH HHS T32 HL007287NIDDK NIH HHS P30 DK017047Seattle Foundation (SF)University of Washington (UW)
6 · The paper itself

Abstract

Chronic obstructive pulmonary disease (COPD), comprised of chronic bronchitis and emphysema, is a leading cause of morbidity and mortality worldwide. Mitogen-activated protein 2 kinase (MAP2K) pathway activation is present in COPD lung tissue and a genetic polymorphism in

Indexed as

Interferon Type IAnimalsInflammationLungMaleMAP Kinase Kinase 1MiceMice, Inbred C57BLMice, KnockoutPneumoniaPulmonary Disease, Chronic ObstructiveReceptor, Interferon alpha-betaSignal TransductionInterferon Type IMap2k1 protein, mouseMAP Kinase Kinase 1Receptor, Interferon alpha-betaCOPDmacrophageMEK1

Identifiers

PMID39316676
PMCPMC11563587

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.