Evidence map›Paper›PMID 39316663›Full record

ArticleScience signaling2024

ProNGF elicits retrograde axonal degeneration of basal forebrain neurons through p75

Srestha Dasgupta, Mansi A Pandya, Juan P Zanin, Tong Liu, Qian Sun, Hong Li, Wilma J Friedman

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science signaling, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Srestha DasguptaDepartment of Biological Sciences, Rutgers University, Newark, NJ 07102, USA.ORCID 0009-0000-5926-5116
Mansi A PandyaDepartment of Biological Sciences, Rutgers University, Newark, NJ 07102, USA.
Juan P ZaninDepartment of Biological Sciences, Rutgers University, Newark, NJ 07102, USA.ORCID 0000-0002-6216-0101
Tong LiuNew Jersey Medical School, Medical Science Building, 185 South Orange Avenue, Newark, NJ 07103, USA.
Qian SunNew Jersey Medical School, Medical Science Building, 185 South Orange Avenue, Newark, NJ 07103, USA.
Hong LiNew Jersey Medical School, Medical Science Building, 185 South Orange Avenue, Newark, NJ 07103, USA.ORCID 0000-0001-5731-5335
Wilma J FriedmanDepartment of Biological Sciences, Rutgers University, Newark, NJ 07102, USA.ORCID 0000-0002-3638-3504

Funding

TBI leads to degeneration of afferent neuronal projectionsR01NS127894 · NINDS · RUTGERS THE STATE UNIV OF NJ NEWARK · PI FRIEDMAN, WILMA J · 2023 to 2025
$1.2M
NINDS NIH HHS R01 NS127894
6 · The paper itself

Abstract

Basal forebrain cholinergic neurons (BFCNs) extend long projections to multiple regions in the brain to regulate cognitive functions. Degeneration of BFCNs is seen with aging, after brain injury, and in neurodegenerative disorders. An increase in the amount of the immature proform of nerve growth factor (proNGF) in the cerebral cortex results in retrograde degeneration of BFCNs through activation of proNGF receptor p75

Indexed as

Amyloid beta-Protein PrecursorAxonsBasal ForebrainNerve Growth FactorAnimalsCells, CulturedCholinergic NeuronsMiceMice, Inbred C57BLNerve DegenerationProtein PrecursorsReceptors, Nerve Growth FactorSignal TransductionAmyloid beta-Protein PrecursorNerve Growth FactorNgfr protein, mousepro-nerve growth factor, mouseProtein PrecursorsReceptors, Nerve Growth Factor

Identifiers

PMID39316663
PMCPMC11487763

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.