Evidence map›Paper›PMID 39316432›Full record

ReviewChembiochem : a European journal of chemical biology2024

Optogenetic Tools for Regulating RNA Metabolism and Functions.

Ru Zheng, Zhaolin Xue, Mingxu You

Abstract readReview
In one paragraph

Review in Chembiochem : a European journal of chemical biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Ru ZhengDepartment of Chemistry, University of Massachusetts, Amherst, MA, 01003, USA.
Zhaolin XueDepartment of Chemistry, University of Massachusetts, Amherst, MA, 01003, USA.
Mingxu YouDepartment of Chemistry, University of Massachusetts, Amherst, MA, 01003, USA.ORCID 0000-0002-5279-2340

Funding

Chemistry-Biology Interface Predoctoral Training GrantT32GM139789 · NIGMS · UNIVERSITY OF MASSACHUSETTS AMHERST · PI ERIC Robert STRIETER · 2021 to 2026
$3.4M
Camille Dreyfus Teacher-Scholar AwardNIGMS NIH HHS T32 GM139789NIH Traineeship T32GM139789NSF CAREER award 1846152
6 · The paper itself

Abstract

RNA molecules play a vital role in linking genetic information with various cellular processes. In recent years, a variety of optogenetic tools have been engineered for regulating cellular RNA metabolism and functions. These highly desirable tools can offer non-intrusive control with spatial precision, remote operation, and biocompatibility. Here, we would like to review these currently available approaches that can regulate RNAs with light: from non-genetically encodable chemically modified oligonucleotides to genetically encoded RNA aptamers that recognize photosensitive small-molecule or protein ligands. Some key applications of these optogenetic tools will also be highlighted to illustrate how they have been used for regulating all aspects of the RNA life cycle: from RNA synthesis, maturation, modification, and translation to their degradation, localization, and phase separation control. Some current challenges and potential practical utilizations of these RNA optogenetic tools will also be discussed.

Indexed as

OptogeneticsRNAAptamers, NucleotideHumansLightAptamers, NucleotideRNAAptamersGenetic engineeringOptogeneticsPhotoswitchesRNA

Identifiers

PMID39316432
PMCPMC11666399

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.