Evidence map›Paper›PMID 39316261›Full record

ArticleCell biochemistry and biophysics2025

Blockade of ITGA2/3/5 Promotes Adipogenic Differentiation of Human Adipose-derived Mesenchymal Stem Cells.

Ying Li, Wendi Wang, Zijian Liu, Guangjing Liu, Xiaobing Li

Abstract read
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In one paragraph

Article in Cell biochemistry and biophysics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ying LiDepartment of Plastic and Burn Surgery, Tianjin First Central Hospital, Tianjin, China.
Wendi WangDepartment of Plastic and Burn Surgery, Tianjin First Central Hospital, Tianjin, China.
Zijian LiuDepartment of Plastic and Burn Surgery, Tianjin First Central Hospital, Tianjin, China.
Guangjing LiuDepartment of Plastic and Burn Surgery, Tianjin First Central Hospital, Tianjin, China.
Xiaobing LiDepartment of Plastic and Burn Surgery, Tianjin First Central Hospital, Tianjin, China. lixiaobing202105@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The integrin α (ITGA) subfamily genes play a fundamental role in various cancers. However, the potential mechanism and application values of ITGA genes in adipogenic differentiation of human adipose-derived stem cells (hADSCs) remain elusive. This study confirmed that ITGA2/3/5 mRNA expressions were repressed during adipogenesis. Blockade of ITGA2/3/5 enhanced adipogenic differentiation of hADSCs. Oil red O staining found that more lipid droplets were apparent in the ITGA2/3/5 inhibition group following 14 d adipogenic induction than in the control group. In addition, inhibition of ITGA2/3/5 promoted the expression of adipogenesis-related genes (PPAR-γ, C/EBPα, FABP4). Mechanistically, ITGA2/3/5 functioned by regulating the Rac1 signaling pathway, which reasonably explains ITGA2/3/5's role in adipogenic differentiation of hADSCs. Our studies suggest that blockades of ITGA2/3/5 promote the adipogenic differentiation of hADSCs.

Indexed as

AdipogenesisAdipose TissueIntegrin alpha2Integrin alpha3Integrin alpha5Integrin alpha ChainsMesenchymal Stem CellsCCAAT-Enhancer-Binding Protein-alphaCell DifferentiationCells, CulturedFatty Acid-Binding ProteinsHumansIntegrinsPPAR gammarac1 GTP-Binding ProteinSignal TransductionCCAAT-Enhancer-Binding Protein-alphaFABP4 protein, humanFatty Acid-Binding ProteinsIntegrin alpha2Integrin alpha3Integrin alpha5Integrin alpha ChainsIntegrinsITGA5 protein, humanPPAR gammarac1 GTP-Binding ProteinRAC1 protein, humanadipocytesdifferentiationhADSCsITGA2/3/5Rac-1 pathway

Identifiers

PMID39316261

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.